Differential effects on white-matter systems in high-functioning autism and Asperger's syndrome
| العنوان: | Differential effects on white-matter systems in high-functioning autism and Asperger's syndrome |
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| المؤلفون: | Vinci Cheung, Grainne M. McAlonan, Se Chua, Ching-Lung Cheung, John Suckling, Nathalie Wong |
| المصدر: | Psychological medicine. 39(11) |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Intelligence, Audiology, behavioral disciplines and activities, Nerve Fibers, Myelinated, Lateralization of brain function, Basal Ganglia, Developmental psychology, Corpus Callosum, White matter, Reference Values, mental disorders, medicine, Humans, Language Development Disorders, Asperger Syndrome, Autistic Disorder, Child, Dominance, Cerebral, Applied Psychology, Brain Mapping, Brain, Organ Size, medicine.disease, Magnetic Resonance Imaging, Frontal Lobe, High-functioning autism, Developmental disorder, Psychiatry and Mental health, medicine.anatomical_structure, Asperger syndrome, Autism spectrum disorder, Laterality, Autism, Female, Agenesis of Corpus Callosum, Psychology |
| الوصف: | BackgroundWhether autism spectrum maps onto a spectrum of brain abnormalities and whether Asperger's syndrome (ASP) is distinct from high-functioning autism (HFA) are debated. White-matter maldevelopment is associated with autism and disconnectivity theories of autism are compelling. However, it is unknown whether children with ASP and HFA have distinct white-matter abnormalities.MethodVoxel-based morphometry mapped white-matter volumes across the whole brain in 91 children. Thirty-six had autism spectrum disorder. A history of delay in phrase speech defined half with HFA; those without delay formed the ASP group. The rest were typically developing children, balanced for age, IQ, gender, maternal language and ethnicity. White-matter volumes in HFA and ASP were compared and each contrasted with controls.ResultsWhite-matter volumes around the basal ganglia were higher in the HFA group than ASP and higher in both autism groups than controls. Compared with controls, children with HFA had less frontal and corpus callosal white matter in the left hemisphere; those with ASP had less frontal and corpus callosal white matter in the right hemisphere with more white matter in the left parietal lobe.ConclusionsHFA involved mainly left hemisphere white-matter systems; ASP affected predominantly right hemisphere white-matter systems. The impact of HFA on basal ganglia white matter was greater than ASP. This implies that aetiological factors and management options for autism spectrum disorders may be distinct. History of language acquisition is a potentially valuable marker to refine our search for causes and treatments in autism spectrum. |
| تدمد: | 1469-8978 0033-2917 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30f6331473f45ef742327dd27d6e70a https://pubmed.ncbi.nlm.nih.gov/19356262 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....b30f6331473f45ef742327dd27d6e70a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14698978 00332917 |
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