Kinetic Monte Carlo and Cellular Particle Dynamics Simulations of Multicellular Systems

التفاصيل البيبلوغرافية
العنوان: Kinetic Monte Carlo and Cellular Particle Dynamics Simulations of Multicellular Systems
المؤلفون: Ioan Kosztin, Elijah J. Flenner, Lorant Janosi, Adrian Neagu, Bogdan Barz, Gabor Forgacs
سنة النشر: 2011
مصطلحات موضوعية: Structure formation, Materials science, education, FOS: Physical sciences, Cell Communication, Models, Biological, 01 natural sciences, 03 medical and health sciences, Cell Movement, Spheroids, Cellular, 0103 physical sciences, Embryonic morphogenesis, Animals, Humans, Computer Simulation, Kinetic Monte Carlo, Statistical physics, Physics - Biological Physics, 010306 general physics, Cell Aggregation, 030304 developmental biology, 0303 health sciences, Fusion, Relaxation (iterative method), Multicellular organism, Biological Physics (physics.bio-ph), Dynamic Monte Carlo method, Monte Carlo molecular modeling
الوصف: Computer modeling of multicellular systems has been a valuable tool for interpreting and guiding in vitro experiments relevant to embryonic morphogenesis, tumor growth, angiogenesis and, lately, structure formation following the printing of cell aggregates as bioink particles. Computer simulations based on Metropolis Monte Carlo (MMC) algorithms were successful in explaining and predicting the resulting stationary structures (corresponding to the lowest adhesion energy state). Here we present two alternatives to the MMC approach for modeling cellular motion and self-assembly: (1) a kinetic Monte Carlo (KMC), and (2) a cellular particle dynamics (CPD) method. Unlike MMC, both KMC and CPD methods are capable of simulating the dynamics of the cellular system in real time. In the KMC approach a transition rate is associated with possible rearrangements of the cellular system, and the corresponding time evolution is expressed in terms of these rates. In the CPD approach cells are modeled as interacting cellular particles (CPs) and the time evolution of the multicellular system is determined by integrating the equations of motion of all CPs. The KMC and CPD methods are tested and compared by simulating two experimentally well known phenomena: (1) cell-sorting within an aggregate formed by two types of cells with different adhesivities, and (2) fusion of two spherical aggregates of living cells.
11 pages, 7 figures; submitted to Phys Rev E
اللغة: English
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b301f48a28f59f2ba618c2a882a0e448
http://arxiv.org/abs/1107.0780
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....b301f48a28f59f2ba618c2a882a0e448
قاعدة البيانات: OpenAIRE