Effect of Superoxide Dismutase on Endothelium-Dependent Relaxation of Aorta from Endotoxin-Treated Rabbits
| العنوان: | Effect of Superoxide Dismutase on Endothelium-Dependent Relaxation of Aorta from Endotoxin-Treated Rabbits |
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| المؤلفون: | Katsuya Mikawa, Kahoru Nishina, H. Yaku, Hidefumi Obara, Nobuhiro Maekawa |
| المصدر: | Journal of International Medical Research. 22:113-120 |
| بيانات النشر: | SAGE Publications, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Male, Nitroprusside, medicine.medical_specialty, Endothelium, medicine.medical_treatment, Hemodynamics, Aorta, Thoracic, 030204 cardiovascular system & hematology, Biochemistry, Muscle, Smooth, Vascular, Superoxide dismutase, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, medicine.artery, Internal medicine, medicine, Animals, Saline, Aorta, Lagomorpha, Dose-Response Relationship, Drug, biology, Superoxide Dismutase, business.industry, Biochemistry (medical), Endothelium-derived relaxing factor, Cell Biology, General Medicine, biology.organism_classification, Acetylcholine, Endotoxins, medicine.anatomical_structure, Endocrinology, chemistry, 030220 oncology & carcinogenesis, Anesthesia, Circulatory system, biology.protein, Endothelium, Vascular, Rabbits, business, Muscle Contraction |
| الوصف: | To assess the protective effect of superoxide dismutase (SOD) on the endothelium of aorta in endotoxaemia, we investigated the production of endothelium-derived relaxing factor in aorta obtained from endotoxin-treated rabbits concomitantly receiving SOD or not. Thirty-two male Japanese white rabbits were randomly divided into four groups ( n = 8 for each group): one group receiving saline as a placebo, a second receiving 5 mg/kg endotoxin intravenously, a third receiving 5 mg/kg endotoxin intravenously plus SOD, and a fourth receiving SOD alone. SOD was injected intravenously at a dose of 10 000 U/kg before the endotoxin and was infused continuously at a rate of 15 000 units/kg/h throughout the experiment. The tension of the aorta was recorded in vitro 6 h after the start of in vivo treatment with endotoxin or saline. In the aorta of rabbits receiving endotoxin alone, acetylcholine-induced relaxation was reduced by 50%. The SOD fully restored the reduction of acetylcholine-induced relaxation by endotoxin. Histological studies using photomicroscopy revealed endothelial damage in the endotoxin-treated aorta, which was attenuated in the SOD-treated group. These data suggest that intravenous SOD may be an effective treatment for unstable haemodynamics in endotoxaemia. |
| تدمد: | 1473-2300 0300-0605 |
| DOI: | 10.1177/030006059402200208 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2dba9a2c79811cea221fd0ba66476d7 https://doi.org/10.1177/030006059402200208 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b2dba9a2c79811cea221fd0ba66476d7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14732300 03000605 |
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| DOI: | 10.1177/030006059402200208 |