Tartrolon D, a Cytotoxic Macrodiolide from the Marine-Derived Actinomycete Streptomyces sp. MDG-04-17-069
| العنوان: | Tartrolon D, a Cytotoxic Macrodiolide from the Marine-Derived Actinomycete Streptomyces sp. MDG-04-17-069 |
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| المؤلفون: | Paz Zúñiga, Fernando Reyes, Cristina Crespo, Marta Pérez, Pilar Rodríguez, Carmen Schleissner |
| المصدر: | Journal of Natural Products. 72:2192-2194 |
| بيانات النشر: | American Chemical Society (ACS), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Stereochemistry, Pharmaceutical Science, Antineoplastic Agents, Marine Biology, Streptomyces, Analytical Chemistry, Lactones, chemistry.chemical_compound, Drug Discovery, Humans, Nuclear Magnetic Resonance, Biomolecular, Pharmacology, Molecular Structure, biology, Streptomycetaceae, Organic Chemistry, Biological activity, biology.organism_classification, Complementary and alternative medicine, Biochemistry, chemistry, Cell culture, Molecular Medicine, Hemiacetal, Fermentation, Actinomycetales, Drug Screening Assays, Antitumor, Bacteria |
| الوصف: | Exploration of marine-derived actinomycetes as a source of antitumor compounds has led to the isolation of a new member of the tartrolon series, tartrolon D (4). This new compound was obtained from Streptomyces sp. MDG-04-17-069 fermentation broths and displayed strong cytotoxic activity against three human tumor cell lines. Additionally, the known compound ikarugamycin (5) was also found in the culture broths of the same microorganism. The structure of this new tartrolon was established by a combination of spectroscopic techniques (1D and 2D NMR, HRMS, and UV) as well as by comparison with published data for similar compounds. |
| تدمد: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np9006603 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2637f8610ec5fddcef3f5b1d062f03e https://doi.org/10.1021/np9006603 |
| رقم الانضمام: | edsair.doi.dedup.....b2637f8610ec5fddcef3f5b1d062f03e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15206025 01633864 |
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| DOI: | 10.1021/np9006603 |