Decreased Homocysteine Trans-Sulfuration in Hypertension With Hyperhomocysteinemia: Relationship With Insulin Resistance
| العنوان: | Decreased Homocysteine Trans-Sulfuration in Hypertension With Hyperhomocysteinemia: Relationship With Insulin Resistance |
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| المؤلفون: | Anna Coracina, Diego Cecchet, Edward Kiwanuka, Lucia Puricelli, Paolo Tessari, Monica Vettore |
| المصدر: | The Journal of Clinical Endocrinology & Metabolism. 103:56-63 |
| بيانات النشر: | The Endocrine Society, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Blood Glucose, Male, Hyperhomocysteinemia, medicine.medical_specialty, protein synthesis, Homocysteine, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, glucose disposal, Clinical Biochemistry, 030209 endocrinology & metabolism, transmethylation, 030204 cardiovascular system & hematology, Essential hypertension, homocysteine clearance, Biochemistry, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Insulin resistance, remethylation, Risk Factors, Internal medicine, medicine, Hyperinsulinemia, Humans, trans-sulfuration, Methionine, business.industry, Insulin, Biochemistry (medical), Middle Aged, Prognosis, medicine.disease, chemistry, Case-Control Studies, Hypertension, Insulin Resistance, business, Transmethylation, Sulfur |
| الوصف: | Context Homocysteine is an independent cardiovascular risk factor and is elevated in essential hypertension. Insulin stimulates homocysteine catabolism in healthy individuals. However, the mechanisms of hyperhomocysteinemia and its relationship with insulin resistance in essential hypertension are unknown. Objective To investigate whole body methionine and homocysteine kinetics and the effects of insulin in essential hypertension. Design and Setting Eight hypertensive male subjects and six male normotensive controls were infused with l-[methyl-2H3,1-13C]methionine for 6 hours. In the last 3 hours a euglycemic, hyperinsulinemic clamp was performed. Steady-state methionine and homocysteine kinetics were determined in postabsorptive and hyperinsulinemic conditions. Results Postabsorptive hypertensive subjects had elevated homocysteine concentrations (+30%, P = 0.035) and slightly (by 15% to 20%) but insignificantly lower methionine rates of appearance (Ras) (P = 0.07 to P = 0.05) and utilization for protein synthesis (P = 0.06) than postabsorptive normotensive controls. Hyperinsulinemia suppressed methionine Ra and protein synthesis, whereas it increased homocysteine trans-sulfuration, clearance, and methionine transmethylation (the latter only in the normotensive subjects). However, in the hypertensive subjects trans-sulfuration was significantly lower (P < 0.05) and increased ~50% less [by +1.59 ± 0.34 vs +3.45 ± 0.52 µmol/kg lean body mass (LBM) per hour, P < 0.005] than in normotensive controls. Homocysteine clearance through trans-sulfuration was ~50% lower in hypertensive than in normotensive subjects (P < 0.005). In the hypertensive subjects, insulin-mediated glucose disposal was ~45% lower (460 ± 44 vs 792 ± 67 mg/kg LBM per hour, P < 0.0005) than in normotensive controls and was positively correlated with the increase of trans-sulfuration (P < 0.0015). Conclusions In subjects with essential hypertension, hyperhomocysteinemia is associated with decreased homocysteine trans-sulfuration and probably represents a feature of insulin resistance. |
| تدمد: | 1945-7197 0021-972X |
| DOI: | 10.1210/jc.2017-01076 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b187badd0e8322838920552b2aee9ea3 https://doi.org/10.1210/jc.2017-01076 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b187badd0e8322838920552b2aee9ea3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19457197 0021972X |
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| DOI: | 10.1210/jc.2017-01076 |