G Protein-Coupled Receptors As Regulators of Localized Translation: The Forgotten Pathway?
| العنوان: | G Protein-Coupled Receptors As Regulators of Localized Translation: The Forgotten Pathway? |
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| المؤلفون: | Aurélie Tréfier, Lucie P. Pellissier, Astrid Musnier, Eric Reiter, Florian Guillou, Pascale Crépieux |
| المساهمون: | Physiologie de la reproduction et des comportements [Nouzilly] (PRC), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), European Project: 267196,EC:FP7:PEOPLE,FP7-PEOPLE-2010-COFUND,AGREENSKILLS(2012), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur] (IFCE)-Université de Tours (UT)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique (INRA)-Institut Français du Cheval et de l'Equitation [Saumur]-Université de Tours-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Frontiers in Endocrinology Frontiers in Endocrinology, Frontiers, 2018, 9, ⟨10.3389/fendo.2018.00017⟩ Frontiers in Endocrinology (9), . (2018) Frontiers in Endocrinology, 2018, 9, ⟨10.3389/fendo.2018.00017⟩ Frontiers in Endocrinology, Vol 9 (2018) |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, ACTIN MESSENGER-RNA, Cellular differentiation, Endocrinology, Diabetes and Metabolism, Gene regulatory network, translatome, Review, Biology, BINDING PROTEIN, lcsh:Diseases of the endocrine glands. Clinical endocrinology, 03 medical and health sciences, Endocrinology, local translation, SYNAPTIC PLASTICITY, signalisation, Gene expression, FRAGILE-X-SYNDROME, G protein-coupled receptor, Receptor, [SDV.BDD]Life Sciences [q-bio]/Development Biology, ELONGATION-FACTOR 1-ALPHA, Regulation of gene expression, Messenger RNA, différenciation cellulaire, lcsh:RC648-665, synthèse de protéine, AMPA RECEPTORS, Biologie du développement, traduction de protéines, LONG-TERM DEPRESSION, Translation (biology), récepteur couplé aux protéines G, MENTAL-RETARDATION PROTEIN, differentiation, Development Biology, signal extracellulaire, Cell biology, DENDRITIC SPINES, 030104 developmental biology, signaling, PRIMARY SERTOLI-CELLS, transcriptome |
| الوصف: | International audience; G protein-coupled receptors (GPCRs) exert their physiological function by transducing a complex signaling network that coordinates gene expression and dictates the phenotype of highly differentiated cells. Much is known about the gene networks they transcriptionally regulate upon ligand exposure in a process that takes hours before a new protein is synthesized. However, far less is known about GPCR impact on the translational machinery and subsequent mRNA translation, although this gene regulation level alters the cell phenotype in a strikingly different timescale. In fact, mRNA translation is an early response kinetically connected to signaling events, hence it leads to the synthesis of a new protein within minutes following receptor activation. By these means, mRNA translation is responsive to subtle variations of the extracellular environment. In addition, when restricted to cell subcellular compartments, local mRNA translation contributes to cell micro-specialization, as observed in synaptic plasticity or in cell migration. The mechanisms that control where in the cell an mRNA is translated are starting to be deciphered. But how an extracellular signal triggers such local translation still deserves extensive investigations. With the advent of high-throughput data acquisition, it now becomes possible to review the current knowledge on the translatome that some GPCRs regulate, and how this information can be used to explore GPCR-controlled local translation of mRNAs. |
| وصف الملف: | application/pdf |
| تدمد: | 1664-2392 |
| DOI: | 10.3389/fendo.2018.00017⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b15586a5c60af1976f17818f1735f457 https://pubmed.ncbi.nlm.nih.gov/29456523 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b15586a5c60af1976f17818f1735f457 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16642392 |
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| DOI: | 10.3389/fendo.2018.00017⟩ |