Functional autoantibodies in patients with different forms of dementia
| العنوان: | Functional autoantibodies in patients with different forms of dementia |
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| المؤلفون: | Gerd Wallukat, Johannes Müller, Ingolf Schimke, Harald Prüss |
| المصدر: | PLoS ONE, Vol 13, Iss 3, p e0192778 (2018) PLoS ONE PLOS ONE 13(3), e0192778 (2018). doi:10.1371/journal.pone.0192778 |
| بيانات النشر: | Public Library of Science (PLoS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Physiology, Dementia with Lewy bodies, lcsh:Medicine, Blood Pressure, Disease, medicine.disease_cause, Alzheimer's Disease, Biochemistry, Vascular Medicine, Autoimmunity, Pathogenesis, 0302 clinical medicine, Animal Cells, Immune Physiology, Medicine and Health Sciences, Coronary Heart Disease, Receptor, lcsh:Science, Neurons, Multidisciplinary, Immune System Proteins, immunology [Dementia], Neurodegenerative Diseases, Middle Aged, Neurology, Hypertension, Female, Cellular Types, Research Article, Cerebrovascular Diseases, Immunology, Cardiology, Vascular Dementia, Antibodies, Autoimmune Diseases, 03 medical and health sciences, immunology [Autoimmune Diseases], Protein Domains, Mental Health and Psychiatry, mental disorders, immunology [Autoantibodies], medicine, Dementia, Humans, ddc:610, Vascular dementia, Aged, Autoantibodies, immunology [Receptors, Adrenergic, beta-2], Lewy body, business.industry, lcsh:R, Autoantibody, Biology and Life Sciences, Proteins, Cell Biology, blood [Autoimmune Diseases], medicine.disease, blood [Dementia], 030104 developmental biology, Cellular Neuroscience, blood [Autoantibodies], Lewy Bodies, lcsh:Q, Receptors, Adrenergic, beta-2, business, 030217 neurology & neurosurgery, Neuroscience |
| الوصف: | Dementia in general and Alzheimer’s disease in particular is increasingly seen in association with autoimmunity being causatively or supportively involved in the pathogenesis. Besides classic autoantibodies (AABs) present in dementia patients, there is the new autoantibody class called functional autoantibodies, which is directed against G-protein coupled receptors (GPCRs; GPCR-AABs) and are seen as pathogenic players. However, less is known about dementia patients’ burden with functional autoantibodies. We present here for the first time a study analyzing the prevalence of GPCR-AABs in patients with different dementia forms such as unclassified, Lewy body, vascular and Alzheimer’s dementia. We identified the GPCR-AABs’ specific targets on the receptors and introduced a neutralization strategy for GPCR-AABs. Patients with Alzheimer’s and vascular dementia carried GPCR-AABs targeting the first loop of the alpha1- and the second loop of the beta2-adrenergic receptors (α1-AABs; β2-AABs). Nearly all vascular dementia patients also carry autoantibodies targeting the endothelin A receptor (ETA-AABs). The majority of patients with Lewy body dementia lacked any of the GPCR-AABs. In vitro, the function of the dementia-associated GPCR-AABs could be neutralized by the aptamer BC007. Due to the presence of GPCR-AABs in dementia patients mainly in those suffering from Alzheimer’s and vascular dementia, the orchestra of immune players in these dementia forms, so far preferentially represented by the classic autoantibodies, should be supplemented by functional autoantibodies. As dementia-associated functional autoantibodies could be neutralized by the aptamer BC007, the first step was taken for a new in vivo treatment option in dementia patients who were positive for GPCR-AABs. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0192778 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14a06a26b2cb7f579df5114eddd3247 http://europepmc.org/articles/PMC5851545?pdf=render |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b14a06a26b2cb7f579df5114eddd3247 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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| DOI: | 10.1371/journal.pone.0192778 |