التفاصيل البيبلوغرافية
| العنوان: |
Assessment of Neutrophil Extracellular Traps in Coronary Thrombus of a Case Series of Patients With COVID-19 and Myocardial Infarction |
| المؤلفون: |
María José Coronado, Juan Manuel Escudier, Lorenzo Silva, Carmen Bellas, Ana Royuela, Maria Del Trigo, Paloma Martín, Ana Blasco, Fernando Hernández-Terciado, E. Ramil, Javier Ortega, Diego García, Javier Goicolea |
| المصدر: |
JAMA Cardiology
JAMA Cardiol |
| بيانات النشر: |
American Medical Association (AMA), 2021. |
| سنة النشر: |
2021 |
| مصطلحات موضوعية: |
medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), business.industry, Brief Report, Neutrophil extracellular traps, Disease, 030204 cardiovascular system & hematology, medicine.disease, Pathogenesis, 03 medical and health sciences, 0302 clinical medicine, Coronary thrombosis, Internal medicine, Occlusion, Cardiology, Medicine, cardiovascular diseases, 030212 general & internal medicine, Myocardial infarction, Thrombus, business, Cardiology and Cardiovascular Medicine |
| الوصف: |
IMPORTANCE: Severe coronavirus disease 2019 (COVID-19) is characterized by the intense formation of neutrophil extracellular traps (NETs), leading to the occlusion of microvessels, as shown in pulmonary samples. The occurrence of ST-elevated myocardial infarction (STEMI) is a serious cardiac manifestation of COVID-19; the intrinsic mechanism of coronary thrombosis appears to still be unknown. OBJECTIVE: To determine the role of NETs in coronary thrombosis in patients with COVID-19. DESIGN, SETTING, AND PARTICIPANTS: This was a consecutive series of patients with COVID-19 at an academic tertiary hospital in Madrid, Spain, who underwent primary coronary interventions for STEMI in which coronary aspirates were obtained in the catheterization laboratory using a thrombus aspiration device. Patients with COVID-19 who experienced a STEMI between March 23 and April 11, 2020, from whom coronary thrombus samples were aspirated during primary coronary intervention, were included in the analysis. These patients were compared with a series conducted from July 2015 to December 2015 of patients with STEMI. MAIN OUTCOMES AND MEASURES: The presence and quantity of NETs in coronary aspirates from patients with STEMI and COVID-19. The method for the analysis of NETs in paraffin-embedded coronary thrombi was based on the use of confocal microscopy technology and image analysis for the colocalization of myeloperoxidase-DNA complexes and citrullinated histone H3. Immunohistochemical analysis of thrombi was also performed. Clinical and angiographic variables were prospectively collected. RESULTS: Five patients with COVID-19 were included (4 men [80%]; mean [SD] age, 62 [14] years); the comparison group included 50 patients (44 males [88%]; mean [SD] age, 58 [12] years). NETs were detected in the samples of all 5 patients with COVID-19, and the median density of NETs was 61% (95% CI, 43%-91%). In the historical series of patients with STEMI, NETs were found in 34 of 50 thrombi (68%), and the median NET density was 19% (95% CI, 13%-22%; P |
| اللغة: |
English |
| تدمد: |
2380-6583 |
| DOI: |
10.1001/jamacardio.2020.7308 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ca7058710faf9e3d056ad81b9e284f |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....b0ca7058710faf9e3d056ad81b9e284f |
| قاعدة البيانات: |
OpenAIRE |