Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL
| العنوان: | Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL |
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| المؤلفون: | Yuemang Yaong, Wolfgang Sattler, Uwe J. F. Tietge, Reeni B. Hildebrand, J. Kar Kruijt, Dominique Stengel, Theo J.C. Van Berkel, Miranda Van Eck, Ewa Ninio, Menno Hoekstra, Domenico Praticò |
| المساهمون: | Center for Liver, Digestive and Metabolic Diseases (CLDM), Lifestyle Medicine (LM) |
| المصدر: | Arteriosclerosis thrombosis and vascular biology, 27(11), 2413-2419. LIPPINCOTT WILLIAMS & WILKINS |
| بيانات النشر: | LIPPINCOTT WILLIAMS & WILKINS, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | medicine.medical_specialty, Isoprostane, Antioxidant, medicine.medical_treatment, PARAOXONASE ACTIVITY, medicine.disease_cause, Mice, chemistry.chemical_compound, High-density lipoprotein, HDL cholesterol, antioxidant enzymes, Internal medicine, CHOLESTERYL ESTERS, isoprostanes, medicine, Animals, oxidative stress, mouse models, CORONARY-HEART-DISEASE, Scavenger receptor, Gene knockout, Mice, Knockout, E-DEFICIENT MICE, Aryldialkylphosphatase, Chemistry, FACTOR-ACETYLHYDROLASE, SR-BI, Scavenger Receptors, Class B, ALPHA-TOCOPHEROL METABOLISM, PON1, PLATELET-ACTIVATING-FACTOR, Endocrinology, 1-Alkyl-2-acetylglycerophosphocholine Esterase, Knockout mouse, Diet, Atherogenic, SELECTIVE UPTAKE, Cardiology and Cardiovascular Medicine, HIGH-DENSITY-LIPOPROTEIN, Oxidative stress |
| الوصف: | Objective—In the current study the effect of disruption of SR-BI, a prominent regulator of HDL metabolism, on the activity of the HDL-associated antioxidant enzymes PON1 and PAF-AH as well as in vivo oxidative stress were investigated.Methods and Results—SR-BI deficiency resulted in 1.4-fold (PPPPPPPConclusion—SR-BI deficiency results in a reduced activity of the antioxidant enzyme PON1 and a significant increase in oxidative stress, potentially contributing to the proatherogenic effect of SR-BI deficiency. |
| اللغة: | English |
| تدمد: | 1524-4636 1079-5642 |
| DOI: | 10.1161/ATVBAHA.107.145474 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0984682b019b40310c502fc18f068b0 https://doi.org/10.1161/ATVBAHA.107.145474 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b0984682b019b40310c502fc18f068b0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244636 10795642 |
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| DOI: | 10.1161/ATVBAHA.107.145474 |