Gene Expression Network Analysis of Precursor Lesions in Familial Pancreatic Cancer
| العنوان: | Gene Expression Network Analysis of Precursor Lesions in Familial Pancreatic Cancer |
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| المؤلفون: | Ove B. Schaffalitzky de Muckadell, Ming Tan, Maiken Thyregod Joergensen |
| المصدر: | Tan, M, Schaffalitzky, O B & Jørgensen, M T 2020, ' Gene Expression Network Analysis of Precursor Lesions in Familial Pancreatic Cancer ', Journal of Pancreatic Cancer, vol. 6, no. 1, pp. 73-84 . https://doi.org/10.1089/pancan.2020.0007 Journal of Pancreatic Cancer |
| بيانات النشر: | Mary Ann Liebert Inc, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pancreatic ductal adenocarcinoma, endocrine system diseases, business.industry, Pancreatic Intraepithelial Neoplasia, precursor lesions, familial pancreatic cancer, network-based analysis, digestive system diseases, Gene expression, Familial Pancreatic Cancer, gene expression, Cancer research, Medicine, Original Article, business, sporadic pancreatic cancer |
| الوصف: | Purpose: High-grade pancreatic intraepithelial neoplasia (PanIN) are aggressive premalignant lesions, associated with risk of progression to pancreatic ductal adenocarcinoma (PDAC). A depiction of co-dysregulated gene activity in high-grade familial pancreatic cancer (FPC)-related PanIN lesions may characterize the molecular events during the progression from familial PanIN to PDAC.Materials and Methods: We performed weighted gene coexpression network analysis (WGCNA) to identify clusters of coexpressed genes associated with FPC-related PanIN lesions in 13 samples with PanIN-2/3 from FPC predisposed individuals, 6 samples with PDAC from sporadic pancreatic cancer (SPC) patients, and 4 samples of normal donor pancreatic tissue.Results: WGCNA identified seven differentially expressed gene (DEG) modules and two commonly expressed gene (CEG) modules with significant enrichment for Gene Ontology (GO) terms in FPC and SPC, including three upregulated (p Conclusion: FPC-related PanIN lesions exhibit a common molecular basis with SPC as shown by gene network activities and commonly expressed high-connectivity hub genes. The differential molecular pathology of FPC and SPC involves multiple coexpressed gene clusters enriched for GO terms including extracellular activities and mitochondrion function. |
| وصف الملف: | application/pdf |
| تدمد: | 2475-3246 |
| DOI: | 10.1089/pancan.2020.0007 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b092fd377949ec867cb0ace728a8a244 https://doi.org/10.1089/pancan.2020.0007 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b092fd377949ec867cb0ace728a8a244 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24753246 |
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| DOI: | 10.1089/pancan.2020.0007 |