التفاصيل البيبلوغرافية
| العنوان: |
Combination therapy of eicosapentaenoic acid and pitavastatin for coronary plaque regression evaluated by integrated backscatter intravascular ultrasonography (CHERRY study)—Rationale and design |
| المؤلفون: |
Takuya Miyamoto, Hiroki Takahashi, Fukao Akira, Osamu Hirono, Tetsu Watanabe, Hiroshi Miyawaki, Takehiko Miyasita, Tetsuro Shishido, Motoyuki Matsui, Eiichiro Ikeno, Isao Kubota, Takanori Arimoto, Satoshi Nishiyama, Shigeo Sugawara |
| المصدر: |
Journal of Cardiology. 64(3):236-239 |
| بيانات النشر: |
Elsevier BV, 2014. |
| سنة النشر: |
2014 |
| مصطلحات موضوعية: |
Fish oils, Acute coronary syndrome, medicine.medical_specialty, Time Factors, Statin, Combination therapy, medicine.drug_class, medicine.medical_treatment, Coronary Artery Disease, Coronary artery disease, Internal medicine, Intravascular ultrasound, medicine, Humans, Prospective Studies, cardiovascular diseases, Pitavastatin, Ultrasonography, Interventional, Plaque, medicine.diagnostic_test, business.industry, Percutaneous coronary intervention, medicine.disease, Coronary Vessels, Plaque, Atherosclerotic, Intravascular ultrasound/Doppler, Treatment Outcome, Eicosapentaenoic Acid, Conventional PCI, Quinolines, Cardiology, Drug Therapy, Combination, lipids (amino acids, peptides, and proteins), Cholesterol-lowering drugs, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business, Cardiology and Cardiovascular Medicine, Follow-Up Studies, medicine.drug |
| الوصف: |
Background and purpose Many clinical trials have shown that 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) can significantly reduce coronary artery disease in both primary and secondary prevention. A recent study showed that aggressive lipid-lowering therapy with strong statins could achieve coronary artery plaque regression, as evaluated with gray-scale intravascular ultrasound (IVUS). However, it is unknown whether coronary plaque regression and stabilization are reinforced when eicosapentaenoic acid (EPA) is used with a strong statin. Methods and subjects We aim to assess patients with stable angina or acute coronary syndrome who had undergone successful percutaneous coronary intervention (PCI) with integrated backscatter IVUS (IB-IVUS) guidance. They will be randomly allocated to receive pitavastatin (4 mg), or pitavastatin (4 mg) plus EPA (1800 mg), and prospectively followed for 6–8 months. Results The primary endpoint will be changes in tissue characteristics in coronary plaques, evaluated by IB-IVUS, and secondary endpoints will include absolute changes in coronary plaque volume, serum lipid levels, and inflammatory markers. The safety profile will also be evaluated. Conclusions The combination therapy of EPA and pitavastatin for regression of coronary plaque evaluated by IB-IVUS (CHERRY) study will be the first multicenter study using IB-IVUS to investigate the effects of combination therapy with pitavastatin and EPA on coronary plaque volume and tissue characteristics. |
| تدمد: |
0914-5087 |
| DOI: |
10.1016/j.jjcc.2013.12.008 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0638836528919f21cc832fd70e1f95d |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....b0638836528919f21cc832fd70e1f95d |
| قاعدة البيانات: |
OpenAIRE |