Adequacy of a hospital-wide standard dose of 7mg/kg bodyweight gentamicin sufficient to achieve an adequate prophylactic maximum serum concentration (Cmax) in burn patients undergoing surgical burn wound treatment
| العنوان: | Adequacy of a hospital-wide standard dose of 7mg/kg bodyweight gentamicin sufficient to achieve an adequate prophylactic maximum serum concentration (Cmax) in burn patients undergoing surgical burn wound treatment |
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| المؤلفون: | Tessa M. Bosch, Jan Dokter, Elisabeth J. Ruijgrok, I.M.M.H. Oen, Margriet E. van Baar, Lennaert C.P. Borra |
| المساهمون: | Pharmacy |
| المصدر: | Burns, 42, 8, pp. 1819-1824 Burns, 42, 1819-1824 Burns, 42(8), 1819-1824. Elsevier Ltd. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, 030106 microbiology, Cmax, Critical Care and Intensive Care Medicine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacokinetics, Intensive care, Medicine, 030212 general & internal medicine, Creatinine, business.industry, General Medicine, Serum concentration, Surgery, lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4], chemistry, Anesthesia, Cohort, Emergency Medicine, Gentamicin, business, Total body surface area, medicine.drug |
| الوصف: | Item does not contain fulltext INTRODUCTION: Pharmacokinetics of drugs can be significantly altered in burn patients. The aim of our study was to validate if the current hospital-wide standard dosage of 7mg/kg total bodyweight gentamicin is sufficient to achieve an adequate prophylactic Cmax (Cmax>/=20mg/L). MATERIALS AND METHODS: A prospective observational cohort pharmacokinetic study was conducted in burn patients undergoing surgical burn wound treatment. RESULTS: 36/40 (90%) burn patients undergoing surgical burn wound treatment at Rotterdam Burn Centre (Maasstad Hospital), the Netherlands, achieved adequate prophylactic serum concentrations (Cmax>/=20mg/L) after a single prophylactic intravenous dose of 7mg/kg total bodyweight gentamicin. Total Body Surface Area (TBSA) burned and total bodyweight were statistically significantly correlated with the Cmax, with correlation coefficients of -0.316, 0.443 and p values of 0.047, 0.004, respectively. Other covariates (age, time after injury, serum creatinine, dose, gender, intensive care admittance) were not statistically significantly correlated. Occurrence of postoperative infection was limited (n=1), no statistically significant difference was observed between patients with a therapeutic and patients with a subtherapeutic serum concentration. CONCLUSION: The current hospital-wide standard dosage of 7mg/kg total bodyweight is sufficient to achieve an adequate prophylactic Cmax in burn patients undergoing surgical burn wound treatment. |
| تدمد: | 0305-4179 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04176eb5bebbc5b357e234a62646b45 https://hdl.handle.net/2066/173945 |
| Rights: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....b04176eb5bebbc5b357e234a62646b45 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 03054179 |
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