التفاصيل البيبلوغرافية
| العنوان: |
Myocardial Injury Pattern at MRI in COVID-19 Vaccine-Associated Myocarditis |
| المؤلفون: |
Matteo Fronza, Paaladinesh Thavendiranathan, Victor Chan, Gauri Rani Karur, Jacob A. Udell, Rachel M. Wald, Rachel Hong, Kate Hanneman |
| المصدر: |
Radiology. 304(3) |
| سنة النشر: |
2022 |
| مصطلحات موضوعية: |
Adult, Male, COVID-19 Vaccines, Adolescent, Myocardium, COVID-19, Contrast Media, Magnetic Resonance Imaging, Cine, Gadolinium, Stroke Volume, Middle Aged, Ventricular Function, Left, Myocarditis, Young Adult, Humans, Radiology, Nuclear Medicine and imaging, Female, BNT162 Vaccine, 2019-nCoV Vaccine mRNA-1273, Retrospective Studies |
| الوصف: |
Background There are limited data on the pattern and severity of myocardial injury in patients with COVID-19 vaccination-associated myocarditis. Purpose To describe myocardial injury following COVID-19 vaccination and to compare these findings to other causes of myocarditis. Materials and Methods In this retrospective cohort study, consecutive adult patients with myocarditis with at least one T1-based and at least one T2-based abnormality at cardiac MRI performed at a tertiary referral hospital from December 2019 to November 2021 were included. Patients were classified into one of three groups: myocarditis following COVID-19 vaccination, myocarditis following COVID-19 illness, and other myocarditis not associated with COVID-19 vaccination or illness. Results Of the 92 included patients, 21 (23%) had myocarditis following COVID-19 vaccination (mean age, 31 years ± 14 [SD]; 17 men; messenger RNA-1273 in 12 [57%] and BNT162b2 in nine [43%]). Ten of 92 (11%) patients had myocarditis following COVID-19 illness (mean age, 51 years ± 14; three men) and 61 of 92 (66%) patients had other myocarditis (mean age, 44 years ± 18; 36 men). MRI findings in the 21 patients with vaccine-associated myocarditis included late gadolinium enhancement (LGE) in 17 patients (81%) and left ventricular dysfunction in six (29%). Compared with other causes of myocarditis, patients with vaccine-associated myocarditis had a higher left ventricular ejection fraction and less extensive LGE, even after controlling for age, sex, and time from symptom onset to MRI. The most frequent location of LGE in all groups was subepicardial at the basal inferolateral wall, although septal involvement was less common in vaccine-associated myocarditis. At short-term follow-up (median, 22 days [IQR, 7-48 days]), all patients with vaccine-associated myocarditis were asymptomatic with no adverse events. Conclusion Cardiac MRI demonstrated a similar pattern of myocardial injury in vaccine-associated myocarditis compared with other causes, although abnormalities were less severe, with less frequent septal involvement and no adverse events over the short-term follow-up. © RSNA, 2022 |
| تدمد: |
1527-1315 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc67e5b0ed2d6b592592c09c59c82f5
https://pubmed.ncbi.nlm.nih.gov/35166589 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....afc67e5b0ed2d6b592592c09c59c82f5 |
| قاعدة البيانات: |
OpenAIRE |