Secondary clonal hematologic neoplasia following successful therapy for acute promyelocytic leukemia (APL): A report of two cases and review of the literature
| العنوان: | Secondary clonal hematologic neoplasia following successful therapy for acute promyelocytic leukemia (APL): A report of two cases and review of the literature |
|---|---|
| المؤلفون: | Daria Gaut, Gary J. Schiller, Joshua P. Sasine |
| المصدر: | Leukemia Research Reports Leukemia Research Reports, Vol 9, Iss, Pp 65-71 (2018) |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Acute promyelocytic leukemia, Monosomy, medicine.medical_treatment, FISH, fluorescence in situ hybridization, ATRA, all-trans retinoic acid, Acute myelocytic leukemia (AML), Bioinformatics, lcsh:RC254-282, Therapy-related myelodysplastic syndrome (t-MDS), Article, 03 medical and health sciences, 0302 clinical medicine, Myelodysplastic syndrome (MDS), Acute promyelocytic leukemia apl, immune system diseases, hemic and lymphatic diseases, ATO, arsenic trioxide, medicine, neoplasms, Complete response, Chromosome 7 (human), Chemotherapy, PML-RARalpha, promyelocytic leukemia/Retinoic acid receptor alpha, business.industry, Clonal hematopoiesis, 6-MP, 6-mercaptopurine, Chromosome, Hematology, Secondary clone, CR, complete remission, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Oncology, APL, acute promyelocytic leukemia, t-AML, therapy-related acute myelocytic leukemia, 030220 oncology & carcinogenesis, t- MDS, therapy-related myelodysplastic syndrome, AML, acute myelocytic leukemia, ATG, antithymyocyte globulin, MDS, myelodysplastic syndrome, business, 030215 immunology, Therapy-related acute myelocytic leukemia (t-AML) |
| الوصف: | Although rare, secondary clonal hematologic neoplasia may occur after successful therapy for acute promyelocytic leukemia (APL). These secondary clonal events may be considered therapy-related, but may also be due to an underlying background of clonal hematopoiesis from which both malignancies may develop. In this manuscript, we describe two patients with secondary clones after APL therapy characterized in one patient by deletion of chromosome 11q23 and, in the other, by monosomy of chromosome 7, and also provide a review of all secondary clonal disorders described after APL therapy. We suggest that since most reports identify karyotypic abnormalities not typically associated with chemotherapy, there may be another mechanism underlying secondary clonal development after complete response to initial APL therapy. Keywords: Acute myelocytic leukemia (AML), Secondary clone, Myelodysplastic syndrome (MDS), Therapy-related acute myelocytic leukemia (t-AML), Therapy-related myelodysplastic syndrome (t-MDS) |
| اللغة: | English |
| تدمد: | 2213-0489 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae058c719b83bc8a675a709277b0bfb5 http://europepmc.org/articles/PMC5993360 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ae058c719b83bc8a675a709277b0bfb5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22130489 |
|---|