FGF-2 Stimulates Periodontal Regeneration
| العنوان: | FGF-2 Stimulates Periodontal Regeneration |
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| المؤلفون: | M. Kitamura, M. Akamatsu, M. Machigashira, Y. Hara, R. Sakagami, T. Hirofuji, T. Hamachi, K. Maeda, M. Yokota, J. Kido, T. Nagata, H. Kurihara, S. Takashiba, T. Sibutani, M. Fukuda, T. Noguchi, K. Yamazaki, H. Yoshie, K. Ioroi, T. Arai, T. Nakagawa, K. Ito, S. Oda, Y. Izumi, Y. Ogata, S. Yamada, H. Shimauchi, K. Kunimatsu, M. Kawanami, T. Fujii, Y. Furuichi, T. Furuuchi, T. Sasano, E. Imai, M. Omae, M. Watanuki, S. Murakami |
| المصدر: | Journal of Dental Research. 90:35-40 |
| بيانات النشر: | SAGE Publications, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Periodontal Ligament, Basic fibroblast growth factor, Alveolar Bone Loss, Gingiva, Fibroblast growth factor, Gastroenterology, Surgical Flaps, law.invention, Placebos, chemistry.chemical_compound, Double-Blind Method, Randomized controlled trial, law, Internal medicine, Periodontal Attachment Loss, Alveolar Process, medicine, Ankylosis, Humans, Periodontal Pocket, Gingival Recession, Periodontitis, General Dentistry, Dental alveolus, business.industry, Regeneration (biology), Dental Plaque Index, Middle Aged, medicine.disease, Recombinant Proteins, Surgery, Radiography, Clinical trial, Treatment Outcome, chemistry, Guided Tissue Regeneration, Periodontal, Female, Fibroblast Growth Factor 2, Periodontal Index, Tooth Mobility, Gingival Hemorrhage, business, Follow-Up Studies |
| الوصف: | The efficacy of the local application of recombinant human fibroblast growth factor-2 (FGF-2) in periodontal regeneration has been investigated. In this study, a randomized, double-blind, placebo-controlled clinical trial was conducted in 253 adult patients with periodontitis. Modified Widman periodontal surgery was performed, during which 200 µL of the investigational formulation containing 0% (vehicle alone), 0.2%, 0.3%, or 0.4% FGF-2 was administered to 2- or 3-walled vertical bone defects. Each dose of FGF-2 showed significant superiority over vehicle alone (p < 0.01) for the percentage of bone fill at 36 wks after administration, and the percentage peaked in the 0.3% FGF-2 group. No significant differences among groups were observed in clinical attachment regained, scoring approximately 2 mm. No clinical safety problems, including an abnormal increase in alveolar bone or ankylosis, were identified. These results strongly suggest that topical application of FGF-2 can be efficacious in the regeneration of human periodontal tissue that has been destroyed by periodontitis. |
| تدمد: | 1544-0591 0022-0345 |
| DOI: | 10.1177/0022034510384616 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6bc1af512178070f93c20557788878 https://doi.org/10.1177/0022034510384616 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ad6bc1af512178070f93c20557788878 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15440591 00220345 |
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| DOI: | 10.1177/0022034510384616 |