Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes
| العنوان: | Neuroanatomical Correlates of Dysglycemia in Young Children With Type 1 Diabetes |
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| المؤلفون: | Matthew J, Marzelli, Paul K, Mazaika, Naama, Barnea-Goraly, Tamara, Hershey, Eva, Tsalikian, William, Tamborlane, Nelly, Mauras, Neil H, White, Bruce, Buckingham, Roy W, Beck, Katrina J, Ruedy, Craig, Kollman, Peiyao, Cheng, Allan L, Reiss, Sarah June, Grafeman |
| المصدر: | Diabetes. 63:343-353 |
| بيانات النشر: | American Diabetes Association, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Blood Glucose, Male, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Audiology, computer.software_genre, 03 medical and health sciences, 0302 clinical medicine, Voxel, Internal Medicine, medicine, Humans, Child, Prefrontal cortex, Glycemic, Intelligence Tests, Type 1 diabetes, medicine.diagnostic_test, Intelligence quotient, business.industry, Brain, Magnetic resonance imaging, Cognition, Organ Size, medicine.disease, Magnetic Resonance Imaging, Diabetes Mellitus, Type 1, Child, Preschool, Female, business, Insula, computer, 030217 neurology & neurosurgery |
| الوصف: | Studies of brain structure in type 1 diabetes (T1D) describe widespread neuroanatomical differences related to exposure to glycemic dysregulation in adults and adolescents. In this study, we investigate the neuroanatomical correlates of dysglycemia in very young children with early-onset T1D. Structural magnetic resonance images of the brain were acquired in 142 children with T1D and 68 age-matched control subjects (mean age 7.0 ± 1.7 years) on six identical scanners. Whole-brain volumetric analyses were conducted using voxel-based morphometry to detect regional differences between groups and to investigate correlations between regional brain volumes and measures of glycemic exposure (including data from continuous glucose monitoring). Relative to control subjects, the T1D group displayed decreased gray matter volume (GMV) in bilateral occipital and cerebellar regions (P < 0.001) and increased GMV in the left inferior prefrontal, insula, and temporal pole regions (P = 0.002). Within the T1D group, hyperglycemic exposure was associated with decreased GMV in medial frontal and temporal-occipital regions and increased GMV in lateral prefrontal regions. Cognitive correlations of intelligence quotient to GMV were found in cerebellar-occipital regions and medial prefrontal cortex for control subjects, as expected, but not for the T1D group. Thus, early-onset T1D affects regions of the brain that are associated with typical cognitive development. |
| تدمد: | 1939-327X 0012-1797 |
| DOI: | 10.2337/db13-0179 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad489563bc6d86d548219f292a2cca0d https://doi.org/10.2337/db13-0179 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ad489563bc6d86d548219f292a2cca0d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
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| DOI: | 10.2337/db13-0179 |