Effect of Treatment with GnRH Agonists on New Markers of Bone Metabolism
| العنوان: | Effect of Treatment with GnRH Agonists on New Markers of Bone Metabolism |
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| المؤلفون: | A. Kukuvitis, G. Vlassis, J. Bildiris, J. Papadimas, A. Dimitriadou, Y. Prapas, D. Tsamis |
| المصدر: | Gynecologic and Obstetric Investigation. 47:194-196 |
| بيانات النشر: | S. Karger AG, 1999. |
| سنة النشر: | 1999 |
| مصطلحات موضوعية: | Agonist, medicine.medical_specialty, Bone disease, medicine.drug_class, Urinary system, medicine.medical_treatment, Osteoporosis, Endometriosis, Biology, Peptide hormone, Bone and Bones, Collagen Type I, Bone remodeling, Gonadotropin-Releasing Hormone, Internal medicine, medicine, Humans, Prospective Studies, Chemotherapy, Estradiol, Leiomyoma, Obstetrics and Gynecology, Alkaline Phosphatase, medicine.disease, Isoenzymes, Endocrinology, Reproductive Medicine, Uterine Neoplasms, Alkaline phosphatase, Calcium, Female, Bone Remodeling, Collagen, Peptides, Biomarkers |
| الوصف: | To assess the utility of new markers in monitoring bone turnover during treatment with GnRH agonists, alkaline phosphatase (total and bone specific) and urinary N-telopeptides were measured. 16 women undergoing treatment with GnRH agonists for endometriosis or leiomyomas were studied before and 3 months after the onset of treatment. N-telopeptide levels increased significantly (44% of baseline, p < 0.05). Bone specific alkaline phosphatase (BALP), measured with a new ELISA assay, was more elevated (40% of baseline, p = 0.001) than total ALP (15% of baseline, p < 0.001). In conclusion, in estrogen deficiency states, urinary N-telopeptide measurements provide a quantitative measure of bone resoption. In the assessment of bone formation, BALP determination is move sensitive than total ALP and this may be clinically useful. |
| تدمد: | 1423-002X 0378-7346 |
| DOI: | 10.1159/000010093 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad4350358101a7e6a8d864e880b598ae https://doi.org/10.1159/000010093 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ad4350358101a7e6a8d864e880b598ae |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1423002X 03787346 |
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| DOI: | 10.1159/000010093 |