Production of Interleukin-4 and Other Cytokines following Stimulation of Mast Cell Lines and in vivo Mast Cells/Basophils
| العنوان: | Production of Interleukin-4 and Other Cytokines following Stimulation of Mast Cell Lines and in vivo Mast Cells/Basophils |
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| المؤلفون: | William E. Paul, Jacalyn H. Pierce, Zami Ben-Sasson, Fred D. Finkelman, Robert A. Seder, Graham LeGros, Anne Kagey-Sobotka, Marshall Plaut |
| المصدر: | International Archives of Allergy and Immunology. 94:137-140 |
| بيانات النشر: | S. Karger AG, 1991. |
| سنة النشر: | 1991 |
| مصطلحات موضوعية: | medicine.medical_treatment, Immunology, Stimulation, Receptors, Fc, Basophil, Immunoglobulin E, Cell Line, Mice, Cell surface receptor, medicine, Animals, Immunology and Allergy, Mast Cells, Interleukin 4, Mice, Inbred BALB C, biology, Receptors, IgE, General Medicine, Mast cell, Basophils, Antigens, Differentiation, B-Lymphocyte, Interleukin 33, medicine.anatomical_structure, Cytokine, biology.protein, Cytokines, Interleukin-4 |
| الوصف: | Interleukin-3 (IL-3)-dependent mast cell lines, upon stimulation by calcium ionophores or by FcεRI cross-linking, express mRNA for, and secrete, a distinct pattern of cytokines, similar to those secreted by cloned mouse T cells of the TH2 type. The mast-cell-derived cytokines include IL-3, IL-4, IL-5 and IL-6. Not only in vitro mast cell lines, but also in vivo derived peritoneal mast cells secrete cytokines. An in vivo derived cell, in mouse spleen and bone marrow, secretes IL-4 and other cytokines upon stimulation with calcium ionophores or by FcεRI cross-linking or FcγRII cross-linking. The IL-4-producing cells are highly enriched in the FcεR+ subset of spleen and bone marrow cells. These FcεR+ cells produce large amounts of IL-4, and they have characteristics similar to those of immature mast cells and/or basophils. It is possible that cytokines produced by mast cells and/or basophils participate in allergic inflammatory diseases. |
| تدمد: | 1423-0097 1018-2438 |
| DOI: | 10.1159/000235345 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad149444db2ae4eb95e8f7aae1097880 https://doi.org/10.1159/000235345 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....ad149444db2ae4eb95e8f7aae1097880 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230097 10182438 |
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| DOI: | 10.1159/000235345 |