Interactions of immediate and long-term action regulation in the course and complications of bipolar disorder
| العنوان: | Interactions of immediate and long-term action regulation in the course and complications of bipolar disorder |
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| المؤلفون: | Marijn Lijffijt, Alan C. Swann, Brittany O'Brien, Ramiro Salas, Sanjay J. Mathew |
| المصدر: | Philosophical Transactions of the Royal Society B: Biological Sciences. 374:20180132 |
| بيانات النشر: | The Royal Society, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Bipolar Disorder, Substance-Related Disorders, Articles, medicine.disease, General Biochemistry, Genetics and Molecular Biology, Behavioural sensitization, 030227 psychiatry, Term (time), Inhibition, Psychological, 03 medical and health sciences, Impulsive behaviour, 0302 clinical medicine, Reward, Action (philosophy), Impulsive Behavior, medicine, Humans, Bipolar disorder, General Agricultural and Biological Sciences, Psychology, Neuroscience, 030217 neurology & neurosurgery |
| الوصف: | Immediate and long-term mechanisms interact in the regulation of action. We will examine neurobiology and practical clinical consequences of these interactions. Long-term regulation of immediate behavioural control is based on analogous responses to highly rewarding or stressful stimuli: (i) impulsivity is a failure of the balance between activation and inhibition in the immediate regulation of action. (ii) Sensitization is a persistently exaggerated behavioural or physiological response to highly salient stimuli, such as addictive stimuli or inescapable stress. Sensitization can generalize across classes of stimuli. (iii) Impulsivity, possibly related to poor modulation of catecholaminergic and glutamatergic functions, may facilitate development of long-term sensitized responses to stressful or addictive stimuli. In turn, impulsivity is prominent in sensitized behaviour. (iv) While impulsivity and sensitization are general components of behaviour, their interactions are prominent in the course of bipolar disorder, emphasizing roles of substance-use, recurrent course and stressors. (v) Suicide is a complex and severe behaviour that exemplifies the manner in which impulsivity facilitates behavioural sensitization and is, in turn, increased by it, leading to inherently unpredictable behaviour. (vi) Interactions between impulsivity and sensitization can provide targets for complementary preventive and treatment strategies for severe immediate and long-term behavioural disorders. Progress along these lines will be facilitated by predictors of susceptibility to behavioural sensitization.This article is part of the theme issue ‘Risk taking and impulsive behaviour: fundamental discoveries, theoretical perspectives and clinical implications’. |
| تدمد: | 1471-2970 0962-8436 |
| DOI: | 10.1098/rstb.2018.0132 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acef252f0187fedfdb88c2db13b97b28 https://doi.org/10.1098/rstb.2018.0132 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....acef252f0187fedfdb88c2db13b97b28 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712970 09628436 |
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| DOI: | 10.1098/rstb.2018.0132 |