Prospective Analysis of Falls in Dominant Ataxias
| العنوان: | Prospective Analysis of Falls in Dominant Ataxias |
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| المؤلفون: | Dagmar Timmann, Massimo Pandolfo, Paola Giunti, Sylvia Boesch, Ludger Schöls, C.C.P. Verstappen, B.P.C. van de Warrenburg, Lisa Bunn, Béla Melegh, Emr Fonteyn, Laszlo Baliko, Thomas Klockgether, C. Globas, Bastiaan R. Bloem, T. Schmitz-Hübsch |
| المصدر: | European Neurology, 69, 53-7 European neurology 69(1), 53-57 (2013). doi:10.1159/000342907 European Neurology, 69, 1, pp. 53-7 |
| بيانات النشر: | S. Karger AG, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, DCN MP - Plasticity and memory, Medizin, Functional Neurogenomics Human Movement & Fatigue [DCN 2], Poison control, Occupational safety and health, Recall bias, Injury prevention, Prevalence, Spinocerebellar Ataxias, Humans, Medicine, ddc:610, Longitudinal Studies, Prospective Studies, genetics [Spinocerebellar Ataxias], Prospective cohort study, Aged, Aged, 80 and over, statistics & numerical data [Accidental Falls], complications [Spinocerebellar Ataxias], business.industry, Retrospective cohort study, Middle Aged, Human Movement & Fatigue [DCN MP - Plasticity and memory NCEBP 10], Neurology, Etiology, Physical therapy, Accidental Falls, Female, epidemiology [Spinocerebellar Ataxias], Neurology (clinical), business, Natural history study |
| الوصف: | Item does not contain fulltext In a previous retrospective study, we demonstrated that falls are common and often injurious in dominant spinocerebellar ataxias (SCAs) and that nonataxia features play an important role in these falls. Retrospective surveys are plagued by recall bias for the presence and details of prior falls. We therefore sought to corroborate and extend these retrospective findings by means of a prospective extension of this fall study. 113 patients with SCA1, SCA2, SCA3 or SCA6, recruited from the EuroSCA natural history study, were asked to keep a fall diary in between their annual visits to the participating centres. Additionally, patients completed a detailed questionnaire about the first three falls, to identify specific fall circumstances. Relevant disease characteristics were retrieved from the EuroSCA registry. 84.1% of patients reported at least one fall during a time period of 12 months. Fall-related injuries were common and their frequency increased with that of falls. The presence of nonataxia symptoms was associated with a higher fall frequency. This study confirms that falls are a frequent and serious complication of SCA, and that the presence of nonataxia symptoms is an important etiological factor in its occurrence. |
| تدمد: | 1421-9913 0014-3022 |
| DOI: | 10.1159/000342907 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acda33ea63cf39dd5f4c70fe4c78e867 https://doi.org/10.1159/000342907 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....acda33ea63cf39dd5f4c70fe4c78e867 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219913 00143022 |
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| DOI: | 10.1159/000342907 |