Neurological toxicity due to antimonial treatment for refractory visceral leishmaniasis
| العنوان: | Neurological toxicity due to antimonial treatment for refractory visceral leishmaniasis |
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| المؤلفون: | Misericordia Veciana de las Heras, Sergio Martínez Yélamos, Jordi Pedro Pérez, Marta Maristany Bosch, Nuria Sabé Fernández, Guillermo Cuervo, Elisabeth Matas Martín |
| المصدر: | Clinical Neurophysiology Practice Clinical Neurophysiology Practice, Vol 6, Iss, Pp 164-167 (2021) Dipòsit Digital de la UB Universidad de Barcelona |
| بيانات النشر: | Elsevier, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Myoclonus, Neurosciences. Biological psychiatry. Neuropsychiatry, Case Report, Therapeutics, Electroencephalography, Drug toxicity, 03 medical and health sciences, 0302 clinical medicine, Refractory, Sodium stibogluconate, Leishmaniosi, Physiology (medical), Toxicitat dels medicaments, Neurotoxicity, Medicine, Beta Rhythm, Adverse effect, Leishmaniasis, Beta activity, medicine.diagnostic_test, business.industry, Antimonials, food and beverages, 030208 emergency & critical care medicine, Terapèutica, medicine.disease, Visceral leishmaniasis, Neurology, Anesthesia, Toxicity, Antimonial, Meglumine antimoniate, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery, RC321-571 |
| الوصف: | Highlights • Severe but reversible neurological toxicity due to antimonial treatment is rarely described. • Extrapyramidal symptoms and epileptogenic discharges can be observed. • EEG recordings are required to diagnose possible antimonial neurotoxicity. Introduction Although pentavalent antimonials are no longer considered the first-line therapy for visceral leishmaniasis in the developed world, they are still used in certain geographical areas and in refractory cases. These drugs have a great number of adverse effects; however, neurological toxicity has been rarely reported. Case report We present a 56-year-old woman who required long-term treatment with antimonial drugs due to refractory visceral leishmaniasis and presented clinically with tremor of extremities, myoclonus, gait disturbances and epileptic seizures. The EEG showed increased beta rhythms and generalized epileptogenic activity. She had a slow but favorable response after the withdrawal of antimonials and the initiation of anticonvulsant therapy. Conclusion Severe but reversible neurological toxicity is a rare adverse effect of prolonged antimonial treatment. More EEG record data are needed to support the suspicion of a possible increase of beta rhythms in this situation. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2467-981X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::accdf188a396eae1db1d4957b5f48815 http://europepmc.org/articles/PMC8790161 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....accdf188a396eae1db1d4957b5f48815 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2467981X |
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