Myristicin and phenytoin toxicity in an infant

التفاصيل البيبلوغرافية
العنوان: Myristicin and phenytoin toxicity in an infant
المؤلفون: Henry Suresh David, Sowmya Sampath, Shobhana Sivathanu, Kulandai Kasthuri Rajavelu
بيانات النشر: BMJ Publishing Group, 2014.
سنة النشر: 2014
مصطلحات موضوعية: Phenytoin, Male, PHENYTOIN TOXICITY, Allylbenzene Derivatives, Status epilepticus, Pyrogallol, Article, Myristica, chemistry.chemical_compound, Therapeutic index, Status Epilepticus, Seizures, Benzyl Compounds, Ingestion, Medicine, Humans, heterocyclic compounds, business.industry, digestive, oral, and skin physiology, Infant, Dioxolanes, General Medicine, Discontinuation, nervous system diseases, Myristicin, chemistry, Anesthesia, Midazolam, Anticonvulsants, medicine.symptom, business, medicine.drug
الوصف: A developmentally normal infant presented with repeated episodes of afebrile status epilepticus following nutmeg ingestion. He had developed two episodes of afebrile status epilepticus and had received different treatments earlier, but the details of treatment were not available. On admission, he redeveloped convulsions and loading doses of phenytoin, phenobarbitone and midazolam were administered. However, seizures persisted and extrapyramidal movements, nystagmus and visual dysfunction were noted. Iatrogenic phenytoin toxicity was considered and confirmed by drug levels. His symptoms completely disappeared after discontinuation of phenytoin therapy. The initial seizures were attributed to myristicin, an active component of nutmeg, because of the temporal association. However, the subsequent seizures were due to phenytoin toxicity caused by administration of multiple loading doses. This case highlights that nutmeg, a spice, can cause serious toxic effects like status epilepticus. Furthermore, treatment of status epilepticus with phenytoin can cause iatrogenic seizures due to its narrow therapeutic range.
اللغة: English
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abbe9ef054f1132c8f2ae0560f12e4bd
https://europepmc.org/articles/PMC4054332/
Rights: OPEN
رقم الانضمام: edsair.doi.dedup.....abbe9ef054f1132c8f2ae0560f12e4bd
قاعدة البيانات: OpenAIRE