The Association of Age with the Induction of Drug-metabolizing Enzymes in Human Monocytes
| العنوان: | The Association of Age with the Induction of Drug-metabolizing Enzymes in Human Monocytes |
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| المؤلفون: | K. W. Woodhouse, Hilary Wynne, G. George |
| المصدر: | Age and Ageing. 19:364-367 |
| بيانات النشر: | Oxford University Press (OUP), 1990. |
| سنة النشر: | 1990 |
| مصطلحات موضوعية: | Adult, Male, Aging, medicine.medical_specialty, Adolescent, Frail Elderly, Monocytes, Basal (phylogenetics), In vivo, Internal medicine, Oxidative enzyme, medicine, Humans, Frail elderly, Enzyme inducer, Aged, chemistry.chemical_classification, biology, business.industry, General Medicine, Middle Aged, Aryl Hydrocarbon Hydroxylases, Drug metabolizing enzymes, Endocrinology, Enzyme, Pharmaceutical Preparations, chemistry, Enzyme Induction, biology.protein, Female, Geriatrics and Gerontology, business |
| الوصف: | In vivo studies in man suggest that the enzyme-inducing effect of environmental influences such as drugs or smoking may be reduced in elderly people. We have investigated the basal activity and response to induction of the oxidative enzyme, aryl hydrocarbon hydroxylase (AHH) in human monocytes. Three groups were studied: ten fit young, ten fit elderly and eight frail elderly subjects. Significant induction of AHH activity in response to the hydrocarbon benz(a)anthracene was achieved in all three groups. No impairment of basal AHH activity or in the synthesis of new enzyme protein was noted with age or frailty. There is still no direct evidence of an age-associated fall in drug metabolizing enzyme activities in man. |
| تدمد: | 1468-2834 0002-0729 |
| DOI: | 10.1093/ageing/19.6.364 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab569146286fec39075a826cd888b92b https://doi.org/10.1093/ageing/19.6.364 |
| رقم الانضمام: | edsair.doi.dedup.....ab569146286fec39075a826cd888b92b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14682834 00020729 |
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| DOI: | 10.1093/ageing/19.6.364 |