Oral Administration of Pharmacologically Active Substances to Squid: A Methodological Description
| العنوان: | Oral Administration of Pharmacologically Active Substances to Squid: A Methodological Description |
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| المؤلفون: | William Berk, Jake Teperman, Rodolfo R. Llinás, Kazunari Hirata, Kerry D. Walton, Mutsuyuki Sugimori |
| المصدر: | The Biological Bulletin. 216:1-6 |
| بيانات النشر: | University of Chicago Press, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Nervous system, Squid, Squid giant synapse, Decapodiformes, Neural Conduction, Administration, Oral, Pharmacology, Neurotransmission, Biology, Coupling (electronics), Electrophysiology, medicine.anatomical_structure, Pharmaceutical Preparations, Piperidines, Oral administration, Postsynaptic potential, biology.animal, Synapses, medicine, Animals, Pyrazoles, Female, General Agricultural and Biological Sciences, Neuroscience |
| الوصف: | The squid giant synapse is a well-defined ex- perimental preparation for the study of ligand-dependant synaptic transmission. Its large size gives direct experimen- tal access to both presynaptic and postsynaptic junctional elements, allowing direct optical, biophysical, and electro- physiological analysis of depolarization-release coupling. However, this important model has not been utilized in pharmacological studies, other than those implementable acutely in the in vitro condition. A method is presented for oral administration of bioactive substances to living squid. Electrophysiological characterization and direct determina- tion of drug absorption into the nervous system demonstrate the administration method described here to be appropriate for pharmacological research. |
| تدمد: | 1939-8697 0006-3185 |
| DOI: | 10.1086/bblv216n1p1 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aae94d68d68f627b11b3fd38ea5b2ba5 https://doi.org/10.1086/bblv216n1p1 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....aae94d68d68f627b11b3fd38ea5b2ba5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19398697 00063185 |
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| DOI: | 10.1086/bblv216n1p1 |