Concerted vs Nonconcerted Metalation-Deprotonation in Orthogonal Direct C-H Arylation of Heterocycles with Halides: A Computational Study

التفاصيل البيبلوغرافية
العنوان: Concerted vs Nonconcerted Metalation-Deprotonation in Orthogonal Direct C-H Arylation of Heterocycles with Halides: A Computational Study
المؤلفون: Vincent Gandon, Christophe Hoarau
المصدر: The Journal of organic chemistry. 86(2)
سنة النشر: 2021
مصطلحات موضوعية: Deprotonation, 010405 organic chemistry, Chemistry, Metalation, Organic Chemistry, Halide, 010402 general chemistry, 01 natural sciences, Medicinal chemistry, 0104 chemical sciences
الوصف: A computational study on the base-assisted orthogonal C-H arylation of azoles with halides is reported. Although concerted metalation-deprotonation (CMD) is favored under acetate assistance at the C5 site that displays the best balance of nucleophilic and acidic character, the most acidic C2 site may be selectively targeted under carbonate assistance by taking advantage of a carbanionic-type (or non-concerted) metalation-deprotonation mechanism (nCMD). For the latter, several experimental probes including base, ligand, and solvent effects have been collected in favor of an outer-sphere deprotonation process after the formation of a [(L
تدمد: 1520-6904
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad4942535f65e1bae064c1cd06732a8
https://pubmed.ncbi.nlm.nih.gov/33406843
Rights: CLOSED
رقم الانضمام: edsair.doi.dedup.....aad4942535f65e1bae064c1cd06732a8
قاعدة البيانات: OpenAIRE