التفاصيل البيبلوغرافية
العنوان:
Data from Hyperpolarized 13C Spectroscopic Imaging Informs on Hypoxia-Inducible Factor-1 and Myc Activity Downstream of Platelet-Derived Growth Factor Receptor
المؤلفون:
Sabrina M. Ronen , Daniel B. Vigneron , Xiaoliang Zhang , Chunsheng Wang , Humsa S. Venkatesh , Christopher S. Ward , Hikari A.I. Yoshihara , Simon Hu , Peder E.Z. Larson , Hagit Dafni
بيانات النشر:
American Association for Cancer Research (AACR), 2023.
سنة النشر:
2023
الوصف:
The recent development of hyperpolarized 13C magnetic resonance spectroscopic imaging provides a novel method for in vivo metabolic imaging with potential applications for detection of cancer and response to treatment. Chemotherapy-induced apoptosis was shown to decrease the flux of hyperpolarized 13C label from pyruvate to lactate due to depletion of NADH, the coenzyme of lactate dehydrogenase. In contrast, we show here that in PC-3MM2 tumors, inhibition of platelet-derived growth factor receptor with imatinib reduces the conversion of hyperpolarized pyruvate to lactate by lowering the expression of lactate dehydrogenase itself. This was accompanied by reduced expression of vascular endothelial growth factor and glutaminase, and is likely mediated by reduced expression of their transcriptional factors hypoxia-inducible factor-1 and c-Myc. Our results indicate that hyperpolarized 13C MRSI could potentially detect the molecular effect of various cell signaling inhibitors, thus providing a radiation-free method to predict tumor response. Cancer Res; 70(19); 7400–10. ©2010 AACR.
DOI:
10.1158/0008-5472.c.6501125
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aac0523ef5e84bcc1d075a7bebcd590c https://doi.org/10.1158/0008-5472.c.6501125
Rights:
OPEN
رقم الانضمام:
edsair.doi.dedup.....aac0523ef5e84bcc1d075a7bebcd590c
قاعدة البيانات:
OpenAIRE