Left Ventricular Ejection Fraction Recovery in Patients with Heart Failure and Reduced Ejection Fraction Treated with Sacubitril/Valsartan
| العنوان: | Left Ventricular Ejection Fraction Recovery in Patients with Heart Failure and Reduced Ejection Fraction Treated with Sacubitril/Valsartan |
|---|---|
| المؤلفون: | Ana Ayesta, Alberto Esteban-Fernández, Javier de Juan-Bagudá, Jesús A Perea-Egido, Manuel Martínez-Sellés, Jorge Salamanca, Pablo Díez-Villanueva, Francisco de la Cuerda, Lourdes Vicent, Marcos García-Aguado, Diego Iglesias, Manuel Gómez-Bueno, Ángel M. Iniesta, Antonio Rojas-González, Ramón Bover-Freire |
| المصدر: | ABACUS. Repositorio de Producción Científica Universidad Europea (UEM) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_treatment, Enfermedad cardiovascular, Tetrazoles, 030204 cardiovascular system & hematology, Sacubitril, Ventricular Function, Left, Cardiac Resynchronization Therapy, Tratamiento médico, 0302 clinical medicine, Outpatients, Pharmacology (medical), 030212 general & internal medicine, Prospective Studies, Registries, Aged, 80 and over, Ejection fraction, Medicamento, Aminobutyrates, Middle Aged, Defibrillators, Implantable, Medicamentos cardiovasculares, Drug Combinations, Treatment Outcome, Valsartan, Cardiology, Female, Cardiology and Cardiovascular Medicine, medicine.drug, medicine.medical_specialty, Cardiac resynchronization therapy, Cardiología, 03 medical and health sciences, Internal medicine, medicine, Humans, In patient, Aged, Heart Failure, business.industry, Biphenyl Compounds, Stroke Volume, Recovery of Function, medicine.disease, Blood pressure, Logistic Models, Heart failure, business, Sacubitril, Valsartan |
| الوصف: | Background: A significant number of heart failure (HF) patients with reduced left ventricular ejection fraction (LVEF) experience ventricular function recovery during follow-up. We studied the variables associated with LVEF recovery in patients treated with sacubitril/valsartan (SV) in clinical practice. Methods: We analyzed data from a prospective and multicenter registry including 249 HF outpatients with reduced LVEF who started SV between October 2016 and March 2017. The patients were classified into 2 groups according to LVEF at the end of follow-up (>35%: group R, or ≤35%: group NR). Results: After a mean follow-up of 7 ± 0.1 months, 62 patients (24.8%) had LVEF >35%. They were older (71.3 ± 10.8 vs. 67.5 ± 12.1 years, p = 0.025), and suffered more often from hypertension (83.9 vs. 73.8%, p = 0.096) and higher blood pressure before and after SV (both, p < 0.01). They took more often high doses of beta-blockers (30.6 vs. 27.8%, p = 0.002), with a smaller proportion undergoing cardiac resynchronization therapy (14.8 vs. 29.0%, p = 0.028) and fewer implanted cardioverter defibrillators (ICD; 32.8 vs. 67.9%, p < 0.001), this being the only predictive variable of NR in the multivariate analysis (OR 0.26, 95% CI 0.13–0.47, p < 0.0001). At the end of follow-up, the mean LVEF in group R was 41.9 ± 8.1% (vs. 26.3 ± 4.7% in group NR, p < 0.001), with an improvement compared with the initial LVEF of 14.6 ± 10.8% (vs. 0.8 ± 4.5% in group NR, p < 0.0001). Functional class improved in both groups, mainly in group R (p = 0.035), with fewer visits to the emergency department (11.5 vs. 21.6%, p = 0.07). Conclusions: In patients with LVEF ≤35% treated with SV, not carrying an ICD was independently associated with LVEF recovery, which was related to greater improvement in functional class. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa5f1240c7aa0547526de63138b8bf72 http://hdl.handle.net/11268/8835 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....aa5f1240c7aa0547526de63138b8bf72 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |