التفاصيل البيبلوغرافية
| العنوان: |
Surfactant Effects on Lipid-Based Vesicles Properties |
| المؤلفون: |
Iftikhar Ahmed Khan, Touraj Ehtezazi, Imran Saleem, Matthew C. Roberts, Ruba Bnyan, Sarah Gordon, Francis O'Neill |
| المصدر: |
Journal of pharmaceutical sciences |
| سنة النشر: |
2018 |
| مصطلحات موضوعية: |
RM, Membrane permeability, Pharmaceutical Science, 02 engineering and technology, 030226 pharmacology & pharmacy, Transfersome, 03 medical and health sciences, Surface-Active Agents, 0302 clinical medicine, Drug Delivery Systems, Pharmacokinetics, Pulmonary surfactant, Zeta potential, Animals, Humans, QD, Liposome, Chemistry, Vesicle, 021001 nanoscience & nanotechnology, Lipids, Hydrophilic-lipophilic balance, Drug Liberation, Pharmaceutical Preparations, Liposomes, Biophysics, 0210 nano-technology, Hydrophobic and Hydrophilic Interactions |
| الوصف: |
Understanding the effect of surfactant properties is critical when designing vesicular delivery systems. This review evaluates previous studies to explain the influence of surfactant properties on the behavior of lipid vesicular systems, specifically their size, charge, stability, entrapment efficiency, pharmacokinetics, and pharmacodynamics. Generally, the size of vesicles decreases by increasing the surfactant concentration, carbon chain length, the hydrophilicity of the surfactant head group, and the hydrophilic-lipophilic balance. Increasing surfactant concentration can also lead to an increase in charge, which in turn reduces vesicle aggregation and enhances the stability of the system. The vesicles' entrapment efficiency not only depends on the surfactant properties but also on the encapsulated drug. For example, the encapsulation of a lipophilic drug could be enhanced by using a surfactant with a low hydrophilic-lipophilic balance value. Moreover, the membrane permeability of vesicles depends on the surfactant's carbon chain length and transition temperature. In addition, surfactants have a clear influence on pharmacokinetics and pharmacodynamics such as sustaining drug release, enhancing the circulation time of vesicles, improving targeting and cellular uptake. |
| وصف الملف: |
application/vnd.openxmlformats-officedocument.wordprocessingml.document; application/pdf |
| اللغة: |
English |
| تدمد: |
0022-3549 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa36847b191fb5c88cf95e7098c4df80 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....aa36847b191fb5c88cf95e7098c4df80 |
| قاعدة البيانات: |
OpenAIRE |