Strategies to Tackle Antimicrobial Resistance: The Example of Escherichia coli and Pseudomonas aeruginosa
| العنوان: | Strategies to Tackle Antimicrobial Resistance: The Example of Escherichia coli and Pseudomonas aeruginosa |
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| المؤلفون: | Rossella Cuffaro, Sonia Nicchi, Serena Tondi, Isabel Delany, Paolo Cinelli, Benedetta Manca, Giacomo Vezzani, Giada Antonelli, Viola Viviani, Maria Scarselli, Luigia Cappelli, Francesca Schiavetti |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 4943, p 4943 (2021) International Journal of Molecular Sciences |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.drug_class, QH301-705.5, 030106 microbiology, Antibiotics, Context (language use), Review, medicine.disease_cause, Catalysis, Microbiology, Inorganic Chemistry, 03 medical and health sciences, Antibiotic resistance, Immune system, Antigen, antimicrobial resistance (AMR), vaccine, Drug Resistance, Bacterial, Escherichia coli, medicine, Animals, Humans, Pseudomonas Infections, Physical and Theoretical Chemistry, Biology (General), Molecular Biology, QD1-999, Escherichia coli Infections, Spectroscopy, outer membrane vesicles (OMV), biology, Pseudomonas aeruginosa, Organic Chemistry, antigen identification, General Medicine, Antimicrobial, biology.organism_classification, Computer Science Applications, monoclonal antibodies (mAbs), Chemistry, 030104 developmental biology, Bacterial Vaccines, Bacteria |
| الوصف: | Traditional antimicrobial treatments consist of drugs which target different essential functions in pathogens. Nevertheless, bacteria continue to evolve new mechanisms to evade this drug-mediated killing with surprising speed on the deployment of each new drug and antibiotic worldwide, a phenomenon called antimicrobial resistance (AMR). Nowadays, AMR represents a critical health threat, for which new medical interventions are urgently needed. By 2050, it is estimated that the leading cause of death will be through untreatable AMR pathogens. Although antibiotics remain a first-line treatment, non-antibiotic therapies such as prophylactic vaccines and therapeutic monoclonal antibodies (mAbs) are increasingly interesting alternatives to limit the spread of such antibiotic resistant microorganisms. For the discovery of new vaccines and mAbs, the search for effective antigens that are able to raise protective immune responses is a challenging undertaking. In this context, outer membrane vesicles (OMV) represent a promising approach, as they recapitulate the complete antigen repertoire that occurs on the surface of Gram-negative bacteria. In this review, we present Escherichia coli and Pseudomonas aeruginosa as specific examples of key AMR threats caused by Gram-negative bacteria and we discuss the current status of mAbs and vaccine approaches under development as well as how knowledge on OMV could benefit antigen discovery strategies. |
| اللغة: | English |
| تدمد: | 1661-6596 1422-0067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9e607ddacfc955d4f4bf5a21c29dbc4 https://www.mdpi.com/1422-0067/22/9/4943 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a9e607ddacfc955d4f4bf5a21c29dbc4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16616596 14220067 |
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