Drosophila ALS Regulates Growth and Metabolism through Functional Interaction with Insulin-like Peptides
| العنوان: | Drosophila ALS Regulates Growth and Metabolism through Functional Interaction with Insulin-like Peptides |
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| المؤلفون: | Charles Géminard, Pierre Léopold, Nathalie Arquier, Gisèle Jarretou, Alexandre Paix, Marc Bourouis, Basil Honegger |
| المساهمون: | Institut de signalisation, biologie du développement et cancer (ISBDC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Zoologisches Institut, Univ Zurich, Universität Zürich [Zürich] = University of Zurich (UZH), Laboratoire de Biologie du Développement de Villefranche sur mer (LBDV), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Observatoire océanologique de Villefranche-sur-mer (OOVM), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Observatoire océanologique de Villefranche-sur-mer (OOVM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Cell Metabolism Cell Metabolism, Elsevier, 2008, 7 (4), pp.333-8. ⟨10.1016/j.cmet.2008.02.003⟩ Cell Metabolism, 2008, 7 (4), pp.333-8. ⟨10.1016/j.cmet.2008.02.003⟩ |
| بيانات النشر: | Elsevier BV, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | MESH: Drosophila, Physiology, medicine.medical_treatment, HUMDISEASE, MESH: Animal Nutrition Physiology, MESH: Insulin-Like Growth Factor Binding Proteins, 0302 clinical medicine, [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB], Drosophila Proteins, MESH: Animals, media_common, Genetics, 0303 health sciences, biology, MESH: Energy Metabolism, Longevity, MESH: Gene Expression Regulation, Insulin-Like Growth Factor Binding Proteins, Biochemistry, SIGNALING, Larva, 030220 oncology & carcinogenesis, Animal Nutritional Physiological Phenomena, Drosophila, MESH: Drosophila Proteins, media_common.quotation_subject, Protein subunit, Blotting, Western, MESH: Stress, 03 medical and health sciences, Somatomedins, Stress, Physiological, medicine, Animals, MESH: Blotting, Western, Drosophila (subgenus), MESH: Somatomedins, Molecular Biology, 030304 developmental biology, Growth factor, Insulin, Lipid metabolism, Metabolism, Cell Biology, MESH: Multiprotein Complexes, biology.organism_classification, Insulin receptor, Gene Expression Regulation, Multiprotein Complexes, biology.protein, Energy Metabolism, MESH: Larva, 030217 neurology & neurosurgery, Function (biology) |
| الوصف: | Summary In metazoans, factors of the insulin family control growth, metabolism, longevity, and fertility in response to environmental cues. In Drosophila , a family of seven insulin-like peptides, called Dilps, activate a common insulin receptor. Some Dilp peptides carry both metabolic and growth functions, raising the possibility that various binding partners specify their functions. Here we identify dALS, the fly ortholog of the vertebrate insulin-like growth factor (IGF)-binding protein acid-labile subunit (ALS), as a Dilp partner that forms a circulating trimeric complex with one molecule of Dilp and one molecule of Imp-L2, an IgG-family molecule distantly related to mammalian IGF-binding proteins (IGFBPs). We further show that dALS antagonizes Dilp function to control animal growth as well as carbohydrate and fat metabolism. These results lead us to propose an evolutionary perspective in which ALS function appeared prior to the separation between metabolic and growth effects that are associated with vertebrate insulin and IGFs. |
| تدمد: | 1550-4131 |
| DOI: | 10.1016/j.cmet.2008.10.005 |
| DOI: | 10.1016/j.cmet.2008.02.003⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95952a8edca456b1a195f97145968ce |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a95952a8edca456b1a195f97145968ce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15504131 |
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| DOI: | 10.1016/j.cmet.2008.10.005 |