Iron deficiency in worsening heart failure is associated with reduced estimated protein intake, fluid retention, inflammation, and antiplatelet use
| العنوان: | Iron deficiency in worsening heart failure is associated with reduced estimated protein intake, fluid retention, inflammation, and antiplatelet use |
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| المؤلفون: | Leong L. Ng, Stefan D. Anker, Dirk J. van Veldhuisen, Chim C. Lang, Niels Grote Beverborg, Kenneth Dickstein, Haye H. van der Wal, Peter van der Meer, Adriaan A. Voors |
| المساهمون: | Cardiovascular Centre (CVC), Restoring Organ Function by Means of Regenerative Medicine (REGENERATE) |
| المصدر: | European Heart Journal, 40(44), 3616-3625. Oxford University Press European Heart Journal |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 030204 cardiovascular system & hematology, Gastroenterology, Eating, 0302 clinical medicine, Interquartile range, Natriuretic Peptide, Brain, CACHEXIA, 030212 general & internal medicine, INDEX, 2. Zero hunger, PARAOXONASE, Anemia, Iron-Deficiency, Hazard ratio, Transferrin, Heart Failure/Cardiomyopathy, Iron Deficiencies, Iron deficiency, Middle Aged, MALNUTRITION, Prognosis, Body Fluids, 3. Good health, PREVALENCE, Cohort, Biomarker (medicine), Female, Cardiology and Cardiovascular Medicine, medicine.medical_specialty, NUTRITIONAL-STATUS, PROGNOSTIC IMPACT, Heart failure, Patient Readmission, 03 medical and health sciences, Clinical Research, Internal medicine, medicine, Humans, Renal Insufficiency, Chronic, Antiplatelets, ANEMIA, Aged, Inflammation, Aryldialkylphosphatase, Tartrate-Resistant Acid Phosphatase, Transferrin saturation, business.industry, MORTALITY, Proteins, Stroke Volume, medicine.disease, Peptide Fragments, MICE, Protein intake, business, Fluid retention, Biomarkers, Platelet Aggregation Inhibitors, Kidney disease |
| الوصف: | Aims Iron deficiency (ID) is common in heart failure (HF) patients and negatively impacts symptoms and prognosis. The aetiology of ID in HF is largely unknown. We studied determinants and the biomarker profile of ID in a large international HF cohort. Methods and results We studied 2357 worsening HF patients from the BIOSTAT-CHF cohort. ID was defined as transferrin saturation Conclusion Our data suggest that the aetiology of ID in worsening HF is complex, multifactorial and seems to consist of a combination of reduced iron uptake (malnutrition, fluid overload), impaired iron storage (inflammation, chronic kidney disease), and iron loss (antiplatelets). |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0195-668X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a94847b13c575e949e222fb4972dec4e https://research.rug.nl/en/publications/468aab4a-51b6-4884-8724-7eb1ce732e11 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a94847b13c575e949e222fb4972dec4e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 0195668X |
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