A new hemiacetal chromone racemate and α-glucosidase inhibitors from Ficus tikoua Bur
| العنوان: | A new hemiacetal chromone racemate and α-glucosidase inhibitors from Ficus tikoua Bur |
|---|---|
| المؤلفون: | Zhou, Qinru, Lei, Xinyu, Niu, Jing, Chen, Yan, Shen, Xiangchun, Zhang, Nenling |
| المصدر: | Natural Product Research. :1-9 |
| بيانات النشر: | Informa UK Limited, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Organic Chemistry, Plant Science, Biochemistry, Analytical Chemistry |
| الوصف: | From the petroleum ether and ethyl acetate portions of the 95% ethanol extract of Ficus tikoua Bur., a new hemiacetal chromone racemate, named (±)-ficunomone (1), together with twenty-two known flavonoids (2-23) were isolated. The new structure was elucidated by NMR, HRESIMS, and X-ray single-crystal diffraction analysis, and the known structures were determined by comparison of spectroscopic data with those reported from literatures. All the compounds were assayed for their inhibitory activities against yeast α-glucosidase, seven flavonoids could inhibit α-glucosidase, among which compounds 22 and 23 exhibited the highest inhibitory activity, with IC50 values at 5.12 ± 0.10 and 3.43 ± 0.15 μM respectively. Preliminary structure and relationship activity of all the compounds was analysed. Kinetic analysis of compounds 22 and 23 indicated that they are both uncompetitive inhibitors. Molecular docking studies revealed that they bound to amino acid residues of the α-glucosidase activity pocket. |
| تدمد: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2022.2068544 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a93ab91fb252ee2518bfb08349362bbc https://doi.org/10.1080/14786419.2022.2068544 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a93ab91fb252ee2518bfb08349362bbc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14786427 14786419 |
|---|---|
| DOI: | 10.1080/14786419.2022.2068544 |