Neuromyelitis optica spectrum disorders and pregnancy: therapeutic considerations
| العنوان: | Neuromyelitis optica spectrum disorders and pregnancy: therapeutic considerations |
|---|---|
| المؤلفون: | M. Isabel Leite, Michelle Fabian, Kerstin Hellwig, Elizabeth A. Mills, Yang Mao-Draayer, Sandra Thiel, Tanuja Chitnis, Sven Jarius, Ilana Katz Sand |
| المصدر: | Nature Reviews Neurology. 16:154-170 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, Pediatrics, medicine.medical_specialty, Breastfeeding, Abortion, Pregnancy planning, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Pre-Eclampsia, Pregnancy, medicine, Humans, Immunologic Factors, Autoimmune disease, business.industry, Neuromyelitis Optica, Abnormalities, Drug-Induced, Retrospective cohort study, medicine.disease, Obstetric Labor Complications, Abortion, Spontaneous, 030104 developmental biology, Neuromyelitis Optica Spectrum Disorders, Childbearing age, Female, Neurology (clinical), business, 030217 neurology & neurosurgery |
| الوصف: | Neuromyelitis optica spectrum disorders (NMOSD) are a type of neurological autoimmune disease characterized by attacks of CNS inflammation that are often severe and predominantly affect the spinal cord and optic nerve. The majority of individuals with NMOSD are women, many of whom are of childbearing age. Although NMOSD are rare, several small retrospective studies and case reports have indicated that pregnancy can worsen disease activity and might contribute to disease onset. NMOSD disease activity seems to negatively affect pregnancy outcomes. Moreover, some of the current NMOSD treatments are known to pose risks to the developing fetus and only limited safety data are available for others. Here, we review published studies regarding the relationship between pregnancy outcomes and NMOSD disease activity. We also assess the risks associated with using disease-modifying therapies for NMOSD during the course of pregnancy and breastfeeding. On the basis of the available evidence, we offer recommendations regarding the use of these therapies in the course of pregnancy planning in individuals with NMOSD. Neuromyelitis optica spectrum disorders (NMOSD) are a type of neurological autoimmune disease characterized by attacks of CNS inflammation. In this Review, the authors discuss the relationship between pregnancy outcomes and NMOSD disease activity, and outline potential treatment approaches. |
| تدمد: | 1759-4766 1759-4758 |
| DOI: | 10.1038/s41582-020-0313-y |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a87ba525045732d256007a82d5dba5de https://doi.org/10.1038/s41582-020-0313-y |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a87ba525045732d256007a82d5dba5de |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17594766 17594758 |
|---|---|
| DOI: | 10.1038/s41582-020-0313-y |