Morphological features of MS lesions on FLAIR* at 7 T and their relation to patient characteristics
| العنوان: | Morphological features of MS lesions on FLAIR* at 7 T and their relation to patient characteristics |
|---|---|
| المؤلفون: | Chris H. Polman, Frederik Barkhof, Jonas A. Castelijns, Peter R. Luijten, Iris D. Kilsdonk, Alexandra Lopez-Soriano, Jeroen J. G. Geurts, Wolter L. de Graaf, Mike P. Wattjes, Joost P.A. Kuijer |
| المساهمون: | Radiology and nuclear medicine, Anatomy and neurosciences, Physics and medical technology, Neurology, NCA - Neuroinflamation, NCA - Brain imaging technology |
| المصدر: | Journal of Neurology, 261(7), 1356-1364. D. Steinkopff-Verlag Kilsdonk, I D, Lopez Soriano, A, Kuijer, J P A, de Graaf, W L, Castelijns, J A, Polman, C H, Luijten, P R, Geurts, J J G, Barkhof, F & Wattjes, M P 2014, ' Morphological features of MS lesions on FLAIR* at 7 T and their relation to patient characteristics ', Journal of Neurology, vol. 261, no. 7, pp. 1356-1364 . https://doi.org/10.1007/s00415-014-7351-6 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Multiple Sclerosis, Neurology, Patient characteristics, Fluid-attenuated inversion recovery, Lesion, Disability Evaluation, Image Processing, Computer-Assisted, Humans, Medicine, Neuroradiology, medicine.diagnostic_test, business.industry, Multiple sclerosis, Brain, Magnetic resonance imaging, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Hyperintensity, Disease Progression, Female, Neurology (clinical), Radiology, medicine.symptom, business, Nuclear medicine |
| الوصف: | Recently, a new MRI technique was developed at 3 Tesla (T), called fluid attenuated inversion recovery* (FLAIR*). In this study, we implemented FLAIR* in an existing MS cohort at 7 T, to investigate whether we could corroborate results of previous 7 T studies that introduced specific MS lesion characteristics. Furthermore, we aimed to investigate the meaning of these lesion characteristics by relating them to clinical characteristics of the MS patient. Three-dimensional FLAIR and T2*-weighted images of 33 MS patients and 7 healthy controls were fused into FLAIR* images. Lesion type, signal intensity and morphology were analysed on FLAIR*, side-by-side with the original FLAIR and T2*, and correlated with clinical characteristics using Spearman’s rho. Three morphological features of MS lesions were visualised: (1) central vessel (CV) within lesions, present in 78 % of total MS lesions; (2) hypointense rims around MS lesions, present in eight patients; (3) FLAIR* lesions that were hypointense at T2*, present in 13 patients. The presence of hypointense (rims around) lesions was not related to clinical characteristics. The simultaneous presence of rimlike lesions and hypointense lesions within MS patients was significantly correlated (ρ = 0.52, P |
| تدمد: | 1432-1459 0340-5354 |
| DOI: | 10.1007/s00415-014-7351-6 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a86c4305eda8cbce1c0c875b83a79481 https://doi.org/10.1007/s00415-014-7351-6 |
| Rights: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....a86c4305eda8cbce1c0c875b83a79481 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14321459 03405354 |
|---|---|
| DOI: | 10.1007/s00415-014-7351-6 |