التفاصيل البيبلوغرافية
العنوان:
Suppression of ErbB-2 in androgen-independent human prostate cancer cells enhances cytotoxic effect by gemcitabine in an androgen-reduced environment
المؤلفون:
Surinder K. Batra , Fen Fen Lin , Li Zhang , Ralph J. Hauke , Rachel Schutte , Thomas L. Davis , Ming Fong Lin , Stanislav Zelivianski , Jeffrey S. Davis
المصدر:
Cancer Letters . 285:58-65
بيانات النشر:
Elsevier BV, 2009.
سنة النشر:
2009
مصطلحات موضوعية:
Male , Oncology , Antimetabolites, Antineoplastic , Cancer Research , medicine.medical_specialty , Time Factors , Combination therapy , Receptor, ErbB-2 , bcl-X Protein , Down-Regulation , Apoptosis , Biology , Deoxycytidine , Article , chemistry.chemical_compound , ErbB , Cell Line, Tumor , Internal medicine , Antineoplastic Combined Chemotherapy Protocols , LNCaP , medicine , Humans , Cytotoxic T cell , Benzothiazoles , Extracellular Signal-Regulated MAP Kinases , Protein Kinase Inhibitors , Cell Proliferation , bcl-2-Associated X Protein , Flavonoids , Dose-Response Relationship, Drug , Prostatic Neoplasms , Cancer , Tyrphostins , medicine.disease , Gemcitabine , Proto-Oncogene Proteins c-bcl-2 , chemistry , Cancer cell , Androgens , Quinazolines , Cancer research , Growth inhibition , medicine.drug
الوصف:
We examined the efficacy of combination treatments utilizing cytotoxic drugs plus inhibitors to members of the ErbB - ERK signal pathway in human prostate cancer (PCa) LNCaP C-81 cells. Under an androgen-reduced condition, 50 nM gemcitabine caused about 40% growth suppression on C-81 cells. Simultaneous treatment of gemcitabine plus 10 µM AG825 produced 60% suppression (p
تدمد:
0304-3835
DOI:
10.1016/j.canlet.2009.04.041
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e893135c2d556f55069d628441c063 https://doi.org/10.1016/j.canlet.2009.04.041
Rights:
OPEN
رقم الانضمام:
edsair.doi.dedup.....a7e893135c2d556f55069d628441c063
قاعدة البيانات:
OpenAIRE