Neisseria meningitidisEndogenous Endophthalmitis with Meningitis in an Immunocompetent Child
| العنوان: | Neisseria meningitidisEndogenous Endophthalmitis with Meningitis in an Immunocompetent Child |
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| المؤلفون: | Imran H. Yusuf, Zuzana Sipkova, Larry Benjamin, Sejal Patel |
| المصدر: | Ocular Immunology and Inflammation. 22:398-402 |
| بيانات النشر: | Informa UK Limited, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | DNA, Bacterial, Male, Anterior Chamber, Endogenous endophthalmitis, Meningitis, Meningococcal, Neisseria meningitidis, Hypopyon, medicine.disease_cause, Meningococcal disease, Polymerase Chain Reaction, Eye Infections, Bacterial, Diagnosis, Differential, Sepsis, Immunocompromised Host, Endophthalmitis, Cerebrospinal fluid, medicine, Humans, Immunology and Allergy, Cerebrospinal Fluid, business.industry, Infant, medicine.disease, Magnetic Resonance Imaging, Meningococcal Infections, Ophthalmology, Immunology, business, Meningitis |
| الوصف: | Neisseria meningitidis is a major cause of childhood morbidity and mortality worldwide. We describe an exceptional case of an immunocompetent 15-month-old child presenting with a unilateral anterior uveitis, hypopyon, and sepsis. Anterior chamber aspirate demonstrated gram-negative cocci before Neisseria meningitidis was identified in blood and cerebrospinal fluid. Meningococcal endophthalmitis presents variably with sepsis, meningitis, or isolated ocular symptoms. Diagnosis is a clinical challenge, requiring diagnostic sampling and treatment from both pediatricians and ophthalmologists. Delayed or incorrect treatment risks blindness, disability, or death. Simultaneous invasion of meningococcus across intact blood-brain and blood-ocular barriers in this child suggests antigenic correlates between meningeal and ocular endothelial interfaces. Meningococcus is an exclusively human pathogen; research is hampered by the lack of animal models. This clinical observation suggests the potential of a novel in vitro experimental approach of using ocular tissue from eye banks to further elucidate the meningococcal-endothelial interaction that underpins meningococcal disease. |
| تدمد: | 1744-5078 0927-3948 |
| DOI: | 10.3109/09273948.2013.854392 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a768c96a68e0025cc5c9bedc75709e16 https://doi.org/10.3109/09273948.2013.854392 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a768c96a68e0025cc5c9bedc75709e16 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17445078 09273948 |
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| DOI: | 10.3109/09273948.2013.854392 |