Molecular Chaperones in Cancer Stem Cells: Determinants of Stemness and Potential Targets for Antitumor Therapy
| العنوان: | Molecular Chaperones in Cancer Stem Cells: Determinants of Stemness and Potential Targets for Antitumor Therapy |
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| المؤلفون: | Anna O Yakimova, Alexander E Kabakov, Olga Matchuk |
| المصدر: | Cells Cells, Vol 9, Iss 892, p 892 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Epithelial-Mesenchymal Transition, medicine.medical_treatment, Review, Biology, heat shock factor 1 (HSF1), Metastasis, glucose-regulated protein (GRP), tumor necrosis factor receptor-associated protein 1 (TRAP1), Hsp27, stem cell phenotype, Cancer stem cell, Heat shock protein, Cell Line, Tumor, medicine, Humans, heat shock protein (HSP), HSF1, lcsh:QH301-705.5, Endoplasmic Reticulum Chaperone BiP, Heat-Shock Proteins, General Medicine, Immunotherapy, medicine.disease, immunophilin, protein disulfide isomerase, lcsh:Biology (General), Cancer cell, Cancer research, biology.protein, Neoplastic Stem Cells, Calreticulin, epithelial-to-mesenchymal transition (EMT), Molecular Chaperones |
| الوصف: | Cancer stem cells (CSCs) are a great challenge in the fight against cancer because these self-renewing tumorigenic cell fractions are thought to be responsible for metastasis dissemination and cases of tumor recurrence. In comparison with non-stem cancer cells, CSCs are known to be more resistant to chemotherapy, radiotherapy, and immunotherapy. Elucidation of mechanisms and factors that promote the emergence and existence of CSCs and their high resistance to cytotoxic treatments would help to develop effective CSC-targeting therapeutics. The present review is dedicated to the implication of molecular chaperones (protein regulators of polypeptide chain folding) in both the formation/maintenance of the CSC phenotype and cytoprotective machinery allowing CSCs to survive after drug or radiation exposure and evade immune attack. The major cellular chaperones, namely heat shock proteins (HSP90, HSP70, HSP40, HSP27), glucose-regulated proteins (GRP94, GRP78, GRP75), tumor necrosis factor receptor-associated protein 1 (TRAP1), peptidyl-prolyl isomerases, protein disulfide isomerases, calreticulin, and also a transcription heat shock factor 1 (HSF1) initiating HSP gene expression are here considered as determinants of the cancer cell stemness and potential targets for a therapeutic attack on CSCs. Various approaches and agents are discussed that may be used for inhibiting the chaperone-dependent development/manifestations of cancer cell stemness. |
| تدمد: | 2073-4409 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a767ff83a22ce3f4ac54e304fb560699 https://pubmed.ncbi.nlm.nih.gov/32268506 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a767ff83a22ce3f4ac54e304fb560699 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734409 |
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