Switchable Catalytic Acrylamide Hydrogels Cross-Linked by Hemin/G-Quadruplexes
| العنوان: | Switchable Catalytic Acrylamide Hydrogels Cross-Linked by Hemin/G-Quadruplexes |
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| المؤلفون: | Huanghao Yang, Ron Orbach, Iris Mironi-Harpaz, Dror Seliktar, Chun-Hua Lu, Itamar Willner, Xiu-Juan Qi |
| المصدر: | Nano Letters. 13:1298-1302 |
| بيانات النشر: | American Chemical Society (ACS), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Luminescence, Bioengineering, Ether, Photochemistry, complex mixtures, Horseradish peroxidase, Catalysis, Dissociation (chemistry), Luminol, chemistry.chemical_compound, General Materials Science, Acrylamide, biology, Mechanical Engineering, technology, industry, and agriculture, Hydrogels, General Chemistry, Condensed Matter Physics, G-Quadruplexes, chemistry, Self-healing hydrogels, biology.protein, Hemin, Oxidation-Reduction |
| الوصف: | Copolymer chains consisting of acrylamide units and guanine (G)-containing oligonucleotide-tethered acrylamide units undergo, in the presence of K(+) ions, cross-linking by G-quadruplexes to yield a hydrogel. The hydrogel is dissociated upon addition of 18-crown-6 ether that traps the K(+) ions. Reversible formation and dissociation of the hydrogel is demonstrated by the cyclic addition of K(+) ions and 18-crown-6 ether, respectively. Formation of the hydrogel in the presence of hemin results in a hemin/G-quadruplex-cross-linked catalytic hydrogel mimicking the function of horseradish peroxidase, reflected by the catalyzed oxidation of 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonic acid), ABTS(2-), by H2O2 to ABTS(·-) and by the catalyzed generation of chemiluminescence in the presence of luminol/H2O2. Cyclic "ON" and "OFF" activation of the catalytic functions of the hydrogel are demonstrated upon the formation of the hydrogel in the presence of K(+) ions and its dissociation by 18-crown-6 ether, respectively. The hydrogel is characterized by rheology measurements, circular dichroism, and probing its chemical and photophysical properties. |
| تدمد: | 1530-6992 1530-6984 |
| DOI: | 10.1021/nl400078g |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a75f2237950bceda003c4ff7f0eb92ee https://doi.org/10.1021/nl400078g |
| رقم الانضمام: | edsair.doi.dedup.....a75f2237950bceda003c4ff7f0eb92ee |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15306992 15306984 |
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| DOI: | 10.1021/nl400078g |