Palladium-Catalyzed Intermolecular Aerobic Oxidative Cyclization of 2-Ethynylanilines with Isocyanides: Regioselective Synthesis of 4-Halo-2-aminoquinolines
| العنوان: | Palladium-Catalyzed Intermolecular Aerobic Oxidative Cyclization of 2-Ethynylanilines with Isocyanides: Regioselective Synthesis of 4-Halo-2-aminoquinolines |
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| المؤلفون: | Yue Yu, Bifu Liu, Hanling Gao, Huanfeng Jiang, Wanqing Wu |
| المصدر: | The Journal of Organic Chemistry. 78:10319-10328 |
| بيانات النشر: | American Chemical Society (ACS), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Oxidative cyclization, Aniline Compounds, Cyanides, Molecular Structure, Acetylene, Chemistry, Organic Chemistry, Intermolecular force, chemistry.chemical_element, Regioselectivity, Stereoisomerism, Combinatorial chemistry, Catalysis, Cyclization, Intramolecular force, Aminoquinolines, Oxidation-Reduction, Palladium |
| الوصف: | A robust and regioselective palladium-catalyzed intermolecular aerobic oxidative cyclization of 2-ethynylanilines with isocyanides to the synthesis of 4-halo-2-aminoquinolines is reported herein. The procedure constructs various 4-halo-2-aminoquinolines with moderate to excellent yields (47-94%) and broad substrates scope. Furthermore, this process can be easily extended to synthesis of various 6H-indolo[2,3-b]quinolines via an intramolecular Buchwald-Hartwig cross-coupling reaction in two-step one-pot manner. |
| تدمد: | 1520-6904 0022-3263 |
| DOI: | 10.1021/jo401707j |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a74fa29359ac122ab71a8bf12deea4af https://doi.org/10.1021/jo401707j |
| رقم الانضمام: | edsair.doi.dedup.....a74fa29359ac122ab71a8bf12deea4af |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15206904 00223263 |
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| DOI: | 10.1021/jo401707j |