Short segment myelitis as the initial and only manifestation of aquaporin-4 immunoglobulin G-positive neuromyelitis optica spectrum disorders
| العنوان: | Short segment myelitis as the initial and only manifestation of aquaporin-4 immunoglobulin G-positive neuromyelitis optica spectrum disorders |
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| المؤلفون: | Zhirong Liu, Wei Fang, Meng-Ting Cai, Yang Zheng, Yin-Xi Zhang, Chun-Hong Shen, Meiping Ding, Fan Yang |
| المصدر: | Therapeutic Advances in Neurological Disorders Therapeutic Advances in Neurological Disorders, Vol 13 (2020) |
| بيانات النشر: | SAGE Publications, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Pathology, medicine.medical_specialty, Autoimmune Neurology, short segment myelitis, Myelitis, multiple sclerosis, lcsh:RC346-429, Immunoglobulin G, 03 medical and health sciences, 0302 clinical medicine, longitudinally extensive transverse myelitis, medicine, lcsh:Neurology. Diseases of the nervous system, Original Research, Pharmacology, biology, aquaporin-4 immunoglobulin G, business.industry, Multiple sclerosis, medicine.disease, 030104 developmental biology, Aquaporin 4, Neurology, Neuromyelitis Optica Spectrum Disorders, Short segment, biology.protein, Neurology (clinical), neuromyelitis optica spectrum disorders, business, 030217 neurology & neurosurgery |
| الوصف: | Background: Short segment myelitis (SSM, < 3 vertebral segments) is an under-recognized initial manifestation of neuromyelitis optica spectrum disorders (NMOSD). Though infrequent, failure to recognize SSM in patients with NMOSD would lead to incorrect diagnosis and treatment. Therefore, delineation of features of NMOSD-associated SSM is of paramount importance. Objective: Our study aimed to determine the demographic, clinical and radiological features of NMOSD-associated SSM, and compare those with NMOSD-associated longitudinally extensive transverse myelitis (LETM) and multiple sclerosis (MS)-associated SSM, respectively. Methods: Chinese patients presenting initially only with acute myelitis and diagnosed with NMOSD ( n = 46) and MS ( n = 11) were included. Clinical, serological, imaging and disability data were collected. Mann–Whitney U test or two-tailed Fisher’s exact tests were used to analyse the data. Results: Of the 46 enrolled NMOSD patients, 34 (74%) collectively had 38 LETM lesions, while 12 (26%) had 14 SSM lesions. When compared with LETM, NMOSD presenting with SSM were more likely to have a delayed diagnosis and a lower level of disability at nadir during the first attack. T1-weighted imaging hypointensity was more prominent in NMOSD-associated LETM lesions than NMOSD-associated SSM lesions. When compared with MS-associated SSM, NMOSD-associated SSM lesions were more likely to be centrally located, grey matter involving and transversally extensive on axial imaging and spanned no less than 2 vertebral segments on sagittal imaging. Conclusion: These findings suggest that SSM does not preclude the possibility of a NMOSD diagnosis. Testing for serum aquaporin-4 immunoglobulin G (AQP4-IgG) and careful study of lesions on spinal cord magnetic resonance imaging could aid in an earlier and correct diagnosis. |
| تدمد: | 1756-2864 |
| DOI: | 10.1177/1756286419898594 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7443a2da1119bd82bd34a8f71479dd5 https://doi.org/10.1177/1756286419898594 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a7443a2da1119bd82bd34a8f71479dd5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17562864 |
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| DOI: | 10.1177/1756286419898594 |