The level and distribution of methyl-esters influence the impact of pectin on intestinal T cells, microbiota, and Ahr activation
| العنوان: | The level and distribution of methyl-esters influence the impact of pectin on intestinal T cells, microbiota, and Ahr activation |
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| المؤلفون: | Beukema, M., Jermendi, Oerlemans, M.M.P., Logtenberg, M.J., Akkerman, R., An, R., van den Berg, M.A., Zoetendal, E.G., Koster, T., Kong, C., Faas, M.M., Schols, H.A., de Vos, P. |
| المساهمون: | Pharmaceutical Technology and Biopharmacy, Translational Immunology Groningen (TRIGR), Reproductive Origins of Adult Health and Disease (ROAHD), Man, Biomaterials and Microbes (MBM) |
| المصدر: | Carbohydrate Polymers 286 (2022) Carbohydrate Polymers, 286:119280. ELSEVIER SCI LTD Carbohydrate Polymers, 286 |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Dietary Fiber, animal structures, Polymers and Plastics, Microbiology, complex mixtures, Aryl-hydrocarbon receptor, Short-chain fatty acids, Mice, Microbiologie, Levensmiddelenchemie, Materials Chemistry, Animals, MolEco, Degree of methyl-esterification, VLAG, Food Chemistry, Microbiota, digestive, oral, and skin physiology, Organic Chemistry, food and beverages, T cell, Esters, Pectin, carbohydrates (lipids), Intestines, Degree of blockiness, Pectins |
| الوصف: | Pectins are dietary fibres that modulate T cell immunity, microbiota composition, and fermentation profiles, but how this is influenced by the degree of methyl-esterification (DM) and degree-of-blockiness (DB) of pectin is unknown. Here, we demonstrate that supplementation of DM19(high-DB), DM49(low-DB) and DM43(high-DB) pectins at a low dose increased the frequencies of intestinal T-helper (Th)1 and Th2 cells after 1 week of pectin supplementation in mice, whereas DM18(low-DB) did not. After 4 weeks of supplementation with those pectins, Th1 and Th2 frequencies returned to control levels, whereas Rorγt+ regulatory T-cell frequencies increased. These structure-dependent effects could derive from induced shifts in microbiota composition that differed between DM18(low-DB) pectin and the other pectins. T-cell-modulating effects were not short-chain-fatty acid-dependent, but rather through an increase in Aryl-hydrocarbon-receptor-activating components. Thus, pectins with a specific combination of DM and DB have an impact on intestinal T cell-immunity in mice, when supplemented at a low dose. |
| وصف الملف: | application/pdf |
| تدمد: | 1879-1344 0144-8617 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a630f6fc3910e25dea2e01e47d0708b5 https://pubmed.ncbi.nlm.nih.gov/35337504 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a630f6fc3910e25dea2e01e47d0708b5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18791344 01448617 |
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