Prevalence of Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Isolates in Nosocomial and Community-Acquired Urinary Tract Infections
| العنوان: | Prevalence of Extended-Spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Isolates in Nosocomial and Community-Acquired Urinary Tract Infections |
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| المؤلفون: | Abolfazl Golipoor, Abolfazl Gholipour, Mohammad Sadegh Damavandi |
| المصدر: | Jundishapur Journal of Microbiology |
| بيانات النشر: | Kowsar, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), Klebsiella pneumoniae, medicine.drug_class, medicine.medical_treatment, 030106 microbiology, Antibiotics, Beta-lactamase SHV-1, Microbiology, Beta-lactamase TEM-1, 03 medical and health sciences, 0302 clinical medicine, Multiplex polymerase chain reaction, medicine, Beta-lactamase VEB-1, 030212 general & internal medicine, biology, biology.organism_classification, Virology, Enterobacteriaceae, Kowsar, Infectious Diseases, Beta-lactamase, Population study, Beta-Lactamases, Bacteria, Research Article |
| الوصف: | Background: Klebsiella pneumoniae is a family member of Enterobacteriaceae. Isolates of K. pneumoniae produce enzymes that cause decomposition of third generation cephalosporins. These enzymes are known as extended-spectrum beta-lactamase (ESBL). Resistance of K. pneumoniae to beta-lactamase antibiotics is commonly mediated by beta-lactamase genes. Objectives: The aim of this study was to identify the ESBL produced by K. pneumoniae isolates that cause community-acquired and nosocomial urinary tract infections within a one-year period (2013 to 2014) in Kashani and Hajar university hospitals of Shahrekord, Iran. Patients and Methods: From 2013 to 2014, 150 strains of K. pneumoniae isolate from two different populations with nosocomial and community-acquired infections were collected. The strains were then investigated by double disk synergism and multiplex polymerase chain reaction (PCR). Results: The study population of 150 patients with nosocomial and community-acquired infections were divided to two groups of 75 each. We found that 48 of the K. pneumoniae isolates in the patients with nosocomial infection and 39 isolates in those with community-acquired infections produced ESBL. The prevalence of TEM1, SHV1 and VEB1 in ESBL-producing isolates in nosocomial patients was 24%, 29.3% and 10.6%, and in community-acquired patients, 17.3%, 22.7% and 8%, respectively. Conclusions: Theprevalence of ESBL-producing K. pneumoniae isolate is of great concern; therefore, continuous investigationseems essential to monitor ESBL-producing bacteria in patients with nosocomial and community-acquired infections. © 2016, Ahvaz Jundishapur University of Medical Sciences. |
| اللغة: | English |
| تدمد: | 2008-4161 2008-3645 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61f355009bdf2bc254c7121f5f6bfe7 http://europepmc.org/articles/PMC4877671 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a61f355009bdf2bc254c7121f5f6bfe7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20084161 20083645 |
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