Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1
| العنوان: | Excitatory neurons of the proprioceptive, interoceptive, and arousal hindbrain networks share a developmental requirement for Math1 |
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| المؤلفون: | Huda Y. Zoghbi, Christina Thaller, Matthew F. Rose, Kaashif A. Ahmad |
| المصدر: | Proceedings of the National Academy of Sciences. 106:22462-22467 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Cerebellum, medicine.medical_specialty, Auditory Pathways, Corticotropin-Releasing Hormone, Nerve net, Glutamic Acid, Mice, Transgenic, Hindbrain, Biology, Nitric Oxide, Arousal, Levodopa, Mice, chemistry.chemical_compound, Pregnancy, Internal medicine, Neural Pathways, Basic Helix-Loop-Helix Transcription Factors, medicine, Animals, Neurotransmitter, Neurons, Multidisciplinary, Glutamate receptor, Gene Expression Regulation, Developmental, Biological Sciences, Proprioception, Acetylcholine, Rhombencephalon, medicine.anatomical_structure, Endocrinology, chemistry, Dorsal column nuclei, Auditory Perception, Excitatory postsynaptic potential, Female, Nerve Net, Somatostatin, Neuroscience |
| الوصف: | Hindbrain networks important for sensation and arousal contain diverse neuronal populations with distinct projections, yet share specific characteristics such as neurotransmitter expression. The relationship between the function of these neurons, their developmental origin, and the timing of their migration remains unclear. Mice lacking the proneural transcription factor Math1 ( Atoh1 ) lose neurons essential for hearing, balance, and unconscious proprioception. By using a new, inducible Math1 Cre * PR allele, we found that Math1 is also required for the conscious proprioceptive system, including excitatory projection neurons of the dorsal column nuclei and for vital components of the interoceptive system, such as Barrington's nucleus, that is closely associated with arousal. In addition to specific networks, Math1 lineages shared specific neurotransmitter expression, including glutamate, acetylcholine, somatostatin, corticotropin releasing hormone, and nitric oxide. These findings identify twenty novel Math1 lineages and indicate that the Math1 network functions partly as an interface for conscious (early-born) and unconscious (late-born) proprioceptive inputs to the cortex and cerebellum, respectively. In addition, these data provide previously unsuspected genetic and developmental links between proprioception, interoception, hearing, and arousal. |
| تدمد: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.0911579106 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5f2e656aa4a180d7f1de1204211c99d https://doi.org/10.1073/pnas.0911579106 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a5f2e656aa4a180d7f1de1204211c99d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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| DOI: | 10.1073/pnas.0911579106 |