Effect of surface morphology change of polystyrene microspheres through etching on protein corona and phagocytic uptake
| العنوان: | Effect of surface morphology change of polystyrene microspheres through etching on protein corona and phagocytic uptake |
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| المؤلفون: | Bin Chen, Zhengzhong Wu, Tingting Feng, Chen Yuanwei, Meng Tian, Xianglin Luo |
| المصدر: | Journal of Biomaterials Science, Polymer Edition. 31:2381-2395 |
| بيانات النشر: | Informa UK Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | endocrine system, Morphology (linguistics), Surface Properties, Phagocytosis, 0206 medical engineering, Biomedical Engineering, Biophysics, Bioengineering, Protein Corona, 02 engineering and technology, Living body, Biomaterials, Macrophage phagocytosis, chemistry.chemical_compound, Etching (microfabrication), Serum Albumin, Bovine, 021001 nanoscience & nanotechnology, 020601 biomedical engineering, Microspheres, chemistry, Chemical engineering, Polystyrene microsphere, Polystyrenes, Adsorption, Polystyrene, 0210 nano-technology |
| الوصف: | Surface physicochemistry properties of polymer particles are crucial for protein corona formation and macrophage phagocytosis when they contact with living body. In this work, polystyrene microspheres (PS-MSs) were selected as a model of polymer microparticles and fabricated by chromic acid etching through controlling conditions to obtain different surface morphology structures and to investigate their effect on the protein adsorption and phagocytic uptake of PS-MSs. The adsorption of bovine serum albumin (BSA) and fibrinogen (FIB) on PS-MSs showed almost the same tendency, i.e. the etched PS-MSs presented lower protein adsorption compared with original microspheres. The adsorption of BSA and FIB was the lowest when the protuberances on the etched surfaces were maximum and the size of the protuberances was minimum. Furthermore, the surface morphologies of PS-MSs were influenced in return not only by the amounts of proteins but also by protein types. Meanwhile, the macrophages phagocytosis of PS-MSs depended on the amounts and kinds of adsorbed proteins, especially the albumin content. In a word, phagocytosis and protein adsorption can be regulated by microsphere morphologies through etching, which provides a promising strategy to avoid invalid uptake for polymer particles such as drug delivery carriers. |
| تدمد: | 1568-5624 0920-5063 |
| DOI: | 10.1080/09205063.2020.1813062 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a596c54370e3b743e3b348f8ca81c9e2 https://doi.org/10.1080/09205063.2020.1813062 |
| رقم الانضمام: | edsair.doi.dedup.....a596c54370e3b743e3b348f8ca81c9e2 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15685624 09205063 |
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| DOI: | 10.1080/09205063.2020.1813062 |