Microbial Metabolites of Ophiobolin A and Antimicrobial Evaluation of Ophiobolins
| العنوان: | Microbial Metabolites of Ophiobolin A and Antimicrobial Evaluation of Ophiobolins |
|---|---|
| المؤلفون: | David P. Rotella, Charles D. Hufford, Erguang Li, Alice M. Clark |
| المصدر: | Journal of Natural Products. 58:74-81 |
| بيانات النشر: | American Chemical Society (ACS), 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Magnetic Resonance Spectroscopy, Sesterterpenes, Stereochemistry, Molecular Sequence Data, Pharmaceutical Science, Microbial Sensitivity Tests, Spectrometry, Mass, Fast Atom Bombardment, Cochliobolus heterostrophus, medicine.disease_cause, Analytical Chemistry, Ophiobolins, Ascomycota, Drug Discovery, Carbohydrate Conformation, medicine, Spectral data, Pharmacology, Polyangium, biology, Terpenes, Pseudomonas aeruginosa, Chemistry, Organic Chemistry, biology.organism_classification, Antimicrobial, Anti-Bacterial Agents, Penicillium patulum, Carbohydrate Sequence, Complementary and alternative medicine, Fermentation, Molecular Medicine |
| الوصف: | Ophiobolin A [1], 3-anhydroophiobolin A [2], ophiobolin B [3], and ophiobolin L [4] were isolated from fermentation broths of Cochliobolus heterostrophus. Preliminary screening showed that a number of organisms were capable of metabolizing the sesterterpene ophiobolin A [1]. Large-scale transformations of ophiobolin A [1] with Polyangium cellulosum produced 6 and 7 while Pseudomonas aeruginosa produced 8. Resting-cell preparations of Penicillium patulum afforded 9 and 10. The structures of these metabolites were established by spectroscopic methods and by comparison of the spectral data with those of the starting material. The antimicrobial activity of the ophiobolins was also evaluated. |
| تدمد: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np50115a009 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56c6dcdccb78b7a065380235c43d95b https://doi.org/10.1021/np50115a009 |
| رقم الانضمام: | edsair.doi.dedup.....a56c6dcdccb78b7a065380235c43d95b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15206025 01633864 |
|---|---|
| DOI: | 10.1021/np50115a009 |