Eph/Ephrin-Mediated Interactions in the Thymus
| العنوان: | Eph/Ephrin-Mediated Interactions in the Thymus |
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| المؤلفون: | David Alfaro, Juan J. Muñoz, Luis Miguel Alonso-Colmenar, Teresa Cejalvo, Agustín G. Zapata, Javier García-Ceca |
| المصدر: | Neuroimmunomodulation. 18:271-280 |
| بيانات النشر: | S. Karger AG, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Cell signaling, Thymocytes, Endocrine and Autonomic Systems, Cellular differentiation, Immunology, Erythropoietin-producing hepatocellular (Eph) receptor, Cell Differentiation, Epithelial Cells, Cell Communication, Thymus Gland, Biology, Cell biology, Endocrinology, EPHB3, Neurology, Cell Movement, Animals, Humans, Ephrin, Lymphoid Progenitor Cells, Signal transduction, Receptor, Ephrins, Signal Transduction |
| الوصف: | In the present study, we review available information on the relevance of Eph and ephrins in numerous processes occurring in the thymus that regulate not only T cell differentiation but also thymic epithelial cell (TEC) development and organization. Eph/ephrins are a large family of receptors and ligands involved in organogenesis and homeostasis of adult tissues. They are extensively expressed in the thymus and seem to be involved in the colonization of lymphoid progenitor cells and their migration throughout the thymic parenchyma necessary to provide an adequate topological location of developing thymocytes in the epithelial network that ensures their correct differentiation. In addition, EphB2 and EphB3 play a cell-autonomous role in regulating the transitions of double-negative to double-positive cells and of double-positive to single-positive thymocytes and the lack of these molecules or their ligands ephrin B1 and ephrin B2 induces profound alterations of the TEC maturation and in the arrangement of epithelial network. We emphasize that these results are largely reflecting the role played by this family of molecules in controlling thymocyte-TEC interactions within the thymus. |
| تدمد: | 1423-0216 1021-7401 |
| DOI: | 10.1159/000329490 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a54f6920cde0ef32f2dc2b333e705f67 https://doi.org/10.1159/000329490 |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a54f6920cde0ef32f2dc2b333e705f67 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230216 10217401 |
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| DOI: | 10.1159/000329490 |