A common limiter circuit for opioid choice and relapse identified in a rodent addiction model
| العنوان: | A common limiter circuit for opioid choice and relapse identified in a rodent addiction model |
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| المؤلفون: | Jasper A. Heinsbroek, Morgan H. James, Megan Josey, Giuseppe Giannotti, Gary Aston-Jones, Jamie Peters, Mitchel R. Mandel |
| المصدر: | Bioessays Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Dendritic spine, General Physics and Astronomy, Self Administration, Nucleus Accumbens, Heroin, Extinction, Psychological, chemistry.chemical_compound, Eating, Recurrence, Neural Pathways, media_common, Cerebral Cortex, Multidisciplinary, Behavior, Animal, Heroin Dependence, Brain, Analgesics, Opioid, medicine.anatomical_structure, Cues, Reinforcement, Psychology, psychological phenomena and processes, medicine.drug, Subsequent Relapse, media_common.quotation_subject, Science, Infralimbic cortex, Decision Making, Drug-Seeking Behavior, Rodentia, Nucleus accumbens, General Biochemistry, Genetics and Molecular Biology, Article, mental disorders, medicine, Animals, business.industry, Addiction, General Chemistry, Opioid-Related Disorders, Rats, Behavior, Addictive, Opioid, Muscimol, chemistry, Food, business, Neuroscience |
| الوصف: | Activity in numerous brain regions drives heroin seeking, but no circuits that limit heroin seeking have been identified. Furthermore, the neural circuits controlling opioid choice are unknown. In this study, we examined the role of the infralimbic cortex (IL) to nucleus accumbens shell (NAshell) pathway during heroin choice and relapse. This model yielded subpopulations of heroin versus food preferring rats during choice, and choice was unrelated to subsequent relapse rates to heroin versus food cues, suggesting that choice and relapse are distinct behavioral constructs. Supporting this, inactivation of the IL with muscimol produced differential effects on opioid choice versus relapse. A pathway-specific chemogenetic approach revealed, however, that the IL-NAshell pathway acts as a common limiter of opioid choice and relapse. Furthermore, dendritic spines in IL-NAshell neurons encode distinct aspects of heroin versus food reinforcement. Thus, opioid choice and relapse share a common addiction-limiting circuit in the IL-NAshell pathway. |
| تدمد: | 2041-1723 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a548c2397ff23f510b13ee795672980d https://pubmed.ncbi.nlm.nih.gov/35357019 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a548c2397ff23f510b13ee795672980d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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