Preoperative chemotherapy could modify recurrence patterns through postoperative complications in patients with gastric cancer

التفاصيل البيبلوغرافية
العنوان: Preoperative chemotherapy could modify recurrence patterns through postoperative complications in patients with gastric cancer
المؤلفون: Naoki Hiki, Hiroki Harada, Masahiro Niihara, Hideki Ushiku, Keishi Yamashita, Ippeita Araki, Kenji Ishido, Marie Washio, Mikiko Sakuraya, Kei Hosoda, Chikatoshi Katada
المصدر: Langenbeck's archives of surgery. 406(4)
سنة النشر: 2020
مصطلحات موضوعية: Stomach neoplasm, medicine.medical_specialty, medicine.medical_treatment, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Gastrectomy, Stomach Neoplasms, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Medicine, Humans, Lymph node, Neoadjuvant therapy, Neoplasm Staging, Retrospective Studies, business.industry, Cancer, Postoperative complication, medicine.disease, medicine.anatomical_structure, Docetaxel, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, Surgery, Neoplasm Recurrence, Local, business, medicine.drug, Abdominal surgery
الوصف: Postoperative infectious complications have a negative impact on survival outcomes in patients with gastric cancer. It is recently reported that preoperative chemotherapy may eliminate this negative impact. This study aimed to confirm whether preoperative chemotherapy can eliminate the negative impact of postoperative infectious complications (IC) on survival outcomes and elucidate the association between postoperative infectious complications and recurrence patterns. We retrospectively reviewed data of 86 patients who received preoperative chemotherapy with docetaxel, cisplatin, and S-1 followed by R0 gastrectomy at the Kitasato University between 2006 and 2016. Patients who developed grade II or higher infectious complications during hospitalization were grouped into the IC group, while others were grouped into the non-IC (NIC) group. Survival outcomes and recurrence patterns were analyzed between the two groups. Infectious complications with Clavien-Dindo classification of grade II or higher were found in 12 patients (14.0%, IC group). The median observational period was 61 months. Overall survival and progression-free survival were similar in the IC and NIC groups. Recurrence occurred in 39 patients. The proportions of peritoneal and lymph node recurrences were not significantly different between the two groups. However, the proportion of distant metastasis in the IC group was significantly higher than that in NIC group (3/4 [75%] vs. 9/35 [17%], p = 0.04). Pathological stage after neoadjuvant therapy plays a stronger role in recurrence than postoperative complications. Lymph node and peritoneal metastasis may be suppressed by preoperative chemotherapy.
تدمد: 1435-2451
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a545c3e2d73b53d8dab6929a5e4fb235
https://pubmed.ncbi.nlm.nih.gov/33745003
Rights: CLOSED
رقم الانضمام: edsair.doi.dedup.....a545c3e2d73b53d8dab6929a5e4fb235
قاعدة البيانات: OpenAIRE