Sphingosine-1-phosphate/sphingosine kinase 1-dependent lymph node metastasis in esophageal squamous cell carcinoma
| العنوان: | Sphingosine-1-phosphate/sphingosine kinase 1-dependent lymph node metastasis in esophageal squamous cell carcinoma |
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| المؤلفون: | Hajime Saito, Yoshihiro Minamiya, Akiyuki Wakita, Souichi Koyota, Satoru Motoyama, Jiajia Liu, Yusuke Sato, Yuta Kawakita |
| المصدر: | Surgery Today. 47:1312-1320 |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Oncology, medicine.medical_specialty, Esophageal Neoplasms, Gene Expression, Lymph node metastasis, Esophageal squamous cell carcinoma, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Sphingosine, Surgical oncology, Internal medicine, medicine, Animals, Humans, Molecular Targeted Therapy, RNA, Messenger, Sphingosine-1-phosphate, Aged, biology, business.industry, General Medicine, Middle Aged, Esophageal cancer, medicine.disease, Disease Models, Animal, Phosphotransferases (Alcohol Group Acceptor), 030104 developmental biology, chemistry, Sphingosine kinase 1, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Carcinoma, Squamous Cell, Cancer research, biology.protein, Female, Surgery, Lysophospholipids, business |
| الوصف: | To establish whether Sphingosine-1-phosphate (S1P) and sphingosine kinase 1 (SphK1) contribute to lymph node metastasis in esophageal squamous cell carcinoma.Immunohistochemical analysis of SphK1 expression was performed using a tissue microarray containing 177 thoracic squamous cell esophageal cancer specimens resected at surgery, to investigate the association between intratumoral SphK1 expression and lymph node metastasis. Serum S1P levels and intratumoral SphK1 mRNA and protein expression were also evaluated in mice with vs. mice without lymph node metastasis in a murine lymph node metastasis model.Among 177 esophageal cancer patients, 127 (72%) were defined as being SphK1-positive. In univariate and multivariate analyses, SphK1 expression status was a significant factor contributing to lymph node metastasis and poorer 5-year overall survival. In the murine lymph node metastasis model, there was no difference in tumor volume or weight between the lymph node metastasis-negative and lymph node metastasis-positive groups. However, levels of SphK1 mRNA and protein and serum S1P levels were all much higher in the metastasis-positive group.S1P/SphK1 may be novel targets for inhibiting lymph node metastasis in esophageal squamous cell carcinoma, and may provide the basis for a therapeutic strategy to suppress lymph node metastasis. |
| تدمد: | 1436-2813 0941-1291 |
| DOI: | 10.1007/s00595-017-1514-x |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d0bbb18cc27329d9e5714f08016675 https://doi.org/10.1007/s00595-017-1514-x |
| Rights: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a4d0bbb18cc27329d9e5714f08016675 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14362813 09411291 |
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| DOI: | 10.1007/s00595-017-1514-x |