Effect of Nifedipine Versus Telmisartan on Prevention of Atrial Fibrillation Recurrence in Hypertensive Patients
| العنوان: | Effect of Nifedipine Versus Telmisartan on Prevention of Atrial Fibrillation Recurrence in Hypertensive Patients |
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| المؤلفون: | Li Su, Weijie Chen, Zengzhang Liu, Xianbin Lan, Peilin Xiao, Shaojie Chen, Yanping Xu, Zhiyu Ling, Bei Zhou, Jinqi Fan, Huaan Du, Yuehui Yin, Kamsang Woo |
| المصدر: | Hypertension. 61:786-792 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Nifedipine, Blood Pressure, Benzoates, law.invention, Electrocardiography, Randomized controlled trial, Heart Rate, law, Internal medicine, Atrial Fibrillation, Heart rate, Secondary Prevention, Internal Medicine, Humans, Medicine, Heart Atria, Prospective Studies, Telmisartan, Prospective cohort study, Dose-Response Relationship, Drug, medicine.diagnostic_test, business.industry, Atrial fibrillation, Middle Aged, Calcium Channel Blockers, medicine.disease, Treatment Outcome, Blood pressure, Echocardiography, Hypertension, Cardiology, Benzimidazoles, Female, business, Angiotensin II Type 1 Receptor Blockers, Follow-Up Studies, medicine.drug |
| الوصف: | It is controversial whether angiotensin II receptor blockers provide better protection than calcium antagonists against atrial fibrillation (AF) recurrence in hypertensive patients. This study was designed to compare the effect of nifedipine- and telmisartan-based antihypertensive treatments for preventing AF recurrence in hypertensive patients with paroxysmal AF. A total of 149 hypertensive patients with paroxysmal AF were randomized to nifedipine- or telmisartan-based antihypertensive treatment groups. The target blood pressure (BP) was P =0.742), and Kaplan–Meier analysis showed no significant difference in the freedom from AF recurrence (log-rank test; P =0.48). However, the rate of developing persistent AF in telmisartan group was lower than that in nifedipine group (5.4% versus 16.0%; P =0.035). Patients in telmisartan group had lower values of left atrial diameter, left atrial volume index, and left ventricular mass index at the end of follow-up. The effects of telmisartan in preventing AF recurrences in hypertensive patients with paroxysmal AF after intensive lowering BP is similar to that of nifedipine, but telmisartan has more potent effects on preventing progression to persistent AF. |
| تدمد: | 1524-4563 0194-911X |
| DOI: | 10.1161/hypertensionaha.111.202309 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a90baf5ae1edfcd674e2e7c983bad8 https://doi.org/10.1161/hypertensionaha.111.202309 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a4a90baf5ae1edfcd674e2e7c983bad8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244563 0194911X |
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| DOI: | 10.1161/hypertensionaha.111.202309 |